MyBioSource.com's Phospho-GCN2 (Thr899) Rabbit mAb is a Rabbit monoclonal antibody. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Western Blot.
Description
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2