MyBioSource.com's Phospho-PKR (Thr446) Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-PKR (Thr446) Rabbit mAb Antibody was generated using EIF2AK2 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Precipitation, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis