MyBioSource.com's Phospho-AMPK alpha 2 (Ser491) Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-AMPK alpha 2 (Ser491) Rabbit mAb Antibody was generated using PRKAA2 as the antigen. It reacts with Homo Sapiens, Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Western Blot.
Description
AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis. AMPK is a heterotrimeric complex composed of a catalytic a subunit and regulatory ß and ? subunits, each of which is encoded by two or three distinct genes (a1, 2; ß1, 2; ?1, 2, 3). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia