The PACRG Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PACRG, and parkin coregulated. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The PACRG Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene