MyBioSource.com's Anti-PGM2L1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The human genome contains five proteins in the alpha-D-phosphohexomutase superfamily. They are epitomized by phosphoglucomutase 1 (PGM1), a critical enzyme in metabolism that regulates glucose homeostasis through the interconversion of glucose 1-phosphate and glucose 6-phosphate. Four other proteins, known as PGM2, PGM2L1, PGM3, and PGM5, are sequence related to PGM1, but differ in their substrate preferences or mechanism, and have distinct biological roles. PGM2 has phosphopentomutase activity, while PGM2L1 (for PGM2-like 1) is specialized for glucose 1,6-bisphosphate (G16P) synthase activity. PGM3 is an N-acetylglucosamine phosphomutase and participates in hexosamine biosynthesis. PGM5 is reported to lack enzyme activity, but has established structural roles in myofibril assembly and maintenance, and is a binding partner for dystrophin. All of these proteins belong to the alpha-D-phosphohexomutase superfamily, which is ubiquitous in all kingdoms of life. Members of the superfamily typically catalyze an intramolecular phosphoryl transfer, often from the 1- to the 6-position of a hexose. Major sub-groups within the enzyme superfamily differ in their preferences for the sugar moiety of their substrates, which include glucose, mannose, glucosamine and N-acetyl glucosamine