MyBioSource.com's ErbB3 (HER3) Rabbit mAb is a Rabbit monoclonal antibody. The ErbB3 (HER3) Rabbit mAb Antibody was generated using ERBB3 as the antigen. It reacts with Homo Sapiens, Human, and Rat. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation