The Rabbit Anti-PDHA1/2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PDHA1, and pyruvate dehydrogenase E1 subunit alpha 1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rabbit Anti-PDHA1/2 Antibody has been shown to work in the following applications: Western Blot.
Description
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]