MyBioSource.com's TGF beta Receptor II Rabbit mAb is a Rabbit monoclonal antibody. The TGF beta Receptor II Rabbit mAb Antibody was generated using TGFBR2 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Western Blot.
Description
TGFßs mediate their activity by high affinity binding to the type II receptor (TGFß RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFß-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFß type I receptor proteins designated ALK-5 (TßR-1) and TSR-1, respectively