The GRP78 BiP Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to HSPA5. This antibody recognizes Homo Sapiens, Human, and Rat antigen. The GRP78 BiP Rabbit mAb Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994)(PubMed 8020977) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER)