MyBioSource.com's Phospho-IRE1 (Ser724) Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-IRE1 (Ser724) Rabbit mAb Antibody was generated using ERN1 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis