The SPRTN Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SPRTN. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The SPRTN Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified