MyBioSource.com's HMGB1 Rabbit mAb is a Rabbit monoclonal antibody. The HMGB1 Rabbit mAb Antibody was generated using HMGB1 as the antigen. It reacts with Homo Sapiens, Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkappaB family, ATF-2 and c-Jun to activate transcription