The Phospho-FGFR1 (Tyr654) Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FGFR1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Phospho-FGFR1 (Tyr654) Rabbit pAb Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766