The E1 Ubiquitin Activating Enzyme Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to UBA1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The E1 Ubiquitin Activating Enzyme Rabbit mAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP