The NEDD8 Activating Enzyme E1C Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to UBA3. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The NEDD8 Activating Enzyme E1C Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene