The Rabbit Anti-Fibrinogen beta Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FGB, and Fibrinogen beta chain. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rabbit Anti-Fibrinogen beta Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, Fibrinogen betas cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of Fibrinogen betand fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]