MyBioSource.com's Pyruvate Dehydrogenase E1 alpha Rabbit mAb is a Rabbit monoclonal antibody. The Pyruvate Dehydrogenase E1 alpha Rabbit mAb Antibody was generated using PDHA1, and pyruvate dehydrogenase E1 subunit alpha 1 as the antigen. It reacts with Homo Sapiens, Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Catalyzes the removal of CO2 from pyruvate. Mutations in the alpha subunits of pyruvate dehydrogenase (E1) lead to congenital defects that are usually associated with lactic acidosis, neurodegeneration and early death