The Recombinant RENT1 Monoclonal Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to UPF1, and UPF1 RNA helicase and ATPase. This antibody recognizes Homo Sapiens, and Human antigen. The Recombinant RENT1 Monoclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene