The Rabbit Anti-Antithrombin III/SERPINC1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SERPINC1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rabbit Anti-Antithrombin III/SERPINC1 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, and Western Blot.
Description
Serpin peptidase inhibitor, clade C(antithrombin), member 1, also known as Antithrombin III(AT3) is the most important inhibitor of thrombin OMBIN III and other coagulation proteinases. This gene is mapped to 1q25.1. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency