The Anti-TAGLN2 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The Anti-TAGLN2 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunoprecipitation, and Western Blot.
Description
Transgelin-2 (TAGLN2) is an actin-binding protein that controls actin stability and promotes T cell activation. TAGLN2 is also expressed on B-cells. TAGLN2 might regulate activation and migration of B-cells, in particular, the entry of activated B-cells into the follicle. TAGLN2 displays a novel function to stabilize cortical F-actin, thereby augmenting F-actin contents at the immunological synapse (IS), and acquiring leukocyte function-associated antigen-1 activation following T cell activation. TAGLN2 also competes with cofilin to protect F-actin in vitro and in vivo. Abnormal expression of TAGLN2 was observed in various types of cancer. TAGLN2 protein plays an important role in multidrug resistance in human breast cancer. siRNA mediated gene silencing of TAGLN2 is a promising strategy for paclitaxel resistance reversal in breast cancer