The JAK2 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to JAK2, and Janus kinase 2. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The JAK2 Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2