The alpha smooth muscle Actin Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to ACTA2. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The alpha smooth muscle Actin Rabbit mAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance