MyBioSource.com's Interferon alpha/beta Receptor 1 Rabbit mAb is a Rabbit monoclonal antibody. The Interferon alpha/beta Receptor 1 Rabbit mAb Antibody was generated using IFNAR1 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway