The INSIG1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to INSIG1. This antibody recognizes Homo Sapiens, Human, and Rat antigen. The INSIG1 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants