MyBioSource.com's Rabbit Anti-NFkappaB-p105/p50 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Rabbit Anti-NFkappaB-p105/p50 Antibody was generated using NFKB1 as the antigen and it reacts with Homo Sapiens, Human, and Mouse.
Description
nuclear factor kappa B subunit 1 (NFkappaB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFkappaB) Protein complex. NFkappaB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFkappaB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkappaB has been associated with a number of inflammatory diseases while persistent inhibition of NFkappaB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof