MyBioSource.com's Rabbit Anti-Osteopontin Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-Osteopontin Antibody was generated using Spp1 as the antigen. It reacts with Homo Sapiens, Human, Rat, and Hamster. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene