The SETD2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SET domain containing 2, histone lysine methyltransferase, and SETD2. This antibody recognizes Homo Sapiens, and Human antigen. The SETD2 Antibody has been shown to work in the following applications: Immunohistochemistry.
Description
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II