MyBioSource.com's PRAME Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry. The PRAME Antibody was generated using PRAME, and PRAME nuclear receptor transcriptional regulator as the antigen and it reacts with Homo Sapiens, and Human.
Description
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants