The HUWE1 Rabbit Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, and HUWE1. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The HUWE1 Rabbit Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is requiredfor the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]