The Rabbit Anti-TGFBR2 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to TGFBR2. This antibody recognizes Homo Sapiens, and Human antigen. The Rabbit Anti-TGFBR2 Antibody has been shown to work in the following applications: Flow Cytometry.
Description
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain; forms a heterodimeric complex with TGF-beta receptor type-1; and binds TGF-beta. This receptor:ligand complex phosphorylates proteins; which then enter the nucleus and regulate the transcription of genes related to cell proliferation; cell cycle arrest; wound healing; immunosuppression; and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome; Loeys-Deitz Aortic Aneurysm Syndrome; and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq; Aug 2017]