The Rabbit Anti-Rad17 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RAD17. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The Rabbit Anti-Rad17 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
RAD17 checkpoint clamp loader component (RAD17) Homo sapiens The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms