MyBioSource.com's cleaved Caspase-9 Rabbit mAb is a Rabbit monoclonal antibody. The cleaved Caspase-9 Rabbit mAb Antibody was generated using CASP9, and Caspase 9 as the antigen. It reacts with Homo Sapiens, Human, and Mouse. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9