The Rabbit Anti-Estrogen Receptor alpha Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to ESR1. This antibody recognizes Homo Sapiens, and Human antigen. The Rabbit Anti-Estrogen Receptor alpha Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites