The IL10 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IL10, and Interleukin 10. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The IL10 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence.
Description
The protein encoded by this gene is cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in miceuggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]