MyBioSource.com's Phospho-IKK beta (Tyr188) Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Phospho-IKK beta (Tyr188) Rabbit pAb Antibody was generated using IKBKB as the antigen and it reacts with Homo Sapiens, Human, Mouse, Rat, and Non-Human Primate.
Description
The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB proteins (1-3). Most agents that activate NF-kappaB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkappaB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IkappaB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits