The Anti-CD325 APC Antibody from MyBioSource.com Monoclonal antibody to Cadherin 2, and Cdh2. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The Anti-CD325 APC Antibody has been shown to work in the following applications: Cell Sorting, Isolation, Flow Cytometry, and Immunofluorescence.
Description
CD325 (N-cadherin) is a type I transmembrane protein, which forms a complex with catenins, that is linked to the actin cytoskeleton. This complex is important in synapses and for functional plasticity of neurons, and is also essential for embryonic development. Decreased CD325 cleavage caused by mutations in presenilin 1 is associated with Alzheimer´s disease. Besides nervous system, CD325 is expressed on the surface of malignant T cells, and increases their adhesion to epithelia, as well as their ability to invade and metastasize to inflammatory sites