The Estrogen Receptor alpha Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to ESR1. This antibody recognizes Homo Sapiens, Human, Mouse, Rat, and Canine antigen. The Estrogen Receptor alpha Rabbit mAb Antibody has been shown to work in the following applications: Precipitation, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites