MyBioSource.com's Rabbit Anti-ErbB 2/EGFR Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-ErbB 2/EGFR Antibody was generated using ERBB2 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase