MyBioSource.com's Osteoprotegerin Rabbit mAb is a Rabbit monoclonal antibody. The Osteoprotegerin Rabbit mAb Antibody was generated using TNFRSF11B as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis