MyBioSource.com's PBX1 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The PBX1 Polyclonal Antibody was generated using PBX homeobox 1, and PBX1 as the antigen and it reacts with Homo Sapiens, Human, and Mouse.
Description
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in miceuggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene