MyBioSource.com's Histone H2A.X Rabbit mAb is a Rabbit monoclonal antibody. The Histone H2A.X Rabbit mAb Antibody was generated using H2A.X variant histone, and H2AX as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, Immunoprecipitation, and Western Blot.
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability