Human/Rhesus Macaque IL-18/IL-1F4 Antibody AF2548 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman/Rhesus Macaque IL-18/IL-1F4 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF2548
ApplicationsBioassay,ELISA,Western Blot,Simple Western,Neutralization,Immunocytochemistry
Conjugate/TagUnconjugated
ReactivityHuman,Rhesus Macaque
Quantity100 ug (also 25 ug)
TargetIL-18/IL-1F4
HostGoat
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant rhesus macaque IL-18/IL-1F4, Tyr37-Asp193, Accession # AAK13416
ConcentrationLYOPH
PurityAntigen Affinity-purified
ValidationKnockout Validated
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameinterleukin 18
NCBI Gene AliasesIGIF, IL-18, IL-1g, IL1F4

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epitheliumCommun BiolMay 13, 2025J. K. Bruce, L. Y. Li, Y. Tang, E. G. Forster, N. J. Winsor, P. Y. Bi, C. Krustev, S. Keely, J. E. Lee, J. R. Rohde, et al.anti-caspase-1 (3866S; Cell Signalling Technology), rabbit anti-Caspase-5 (ab40887; abcam), goat anti- IL-18 (AF2548; Novus Biologicals), anti-Tubulin (T9026, Millipore Sigma, 1/10,000 dilution), LPS (14011S; CST), human

(2) Chemical Tools Based on the Tetrapeptide Sequence of IL-18 Reveals Shared Specificities between Inflammatory and Apoptotic Initiator CaspasesbioRxiv : the preprint server for biologyFebruary 27, 2025Bourne CM, Raniszewski NR, Kulkarni M, Exconde PM, Liu S, Yost W, Wrong TJ, Patio RC, Mahale A, Kardhashi M, et al.Polyclonal Ab,R&D systems,Cat# AF-201-NA; RRID:AB_354387 hIL-18 Goat Polyclonal Ab,R&D systems,Cat# AF2548; RRID:AB_562603 PARP Rabbit polyclonal Ab,Cell Signaling Tech,Cat#9542S; RRID:AB_2160739 HA Rabbit

(3) The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspasesCell reportsDecember 26, 2023Exconde PM, Hernandez-Chavez C, Bourne CM, Richards RM, Bray MB, Lopez JL, Srivastava T, Egan MS, Zhang J, Yoo W, et al.

(4) RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and GliomaInternational journal of molecular sciencesApril 6, 2023Kahm YJ, Kim IG, Kim RK.IL-8/CXCL8 (0.4µg/mL; cat. no. MAB208; R&D SYSTEMS, Minneapolis, MN, USA), and IL-18 (1.2µg/mL; cat. no. AF2548; R&D SYSTEMS, Minneapolis, MN, USA) were used for the neutralization assay. The normal mouse IgG1 antibody

(5) The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspasesbioRxiv : the preprint server for biologyFebruary 16, 2023Exconde PM, Hernandez-Chavez C, Bray MB, Lopez JL, Srivastava T, Egan MS, Zhang J, Shin S, Discher BM, Taabazuing CY.(Cell Signaling Tech, 13202S), hIL-1β Goat Polyclonal Ab (R&D systems, AF-201-NA), hIL-18 Goat Ab (R&D systems, af2548), hIL-1α Recombinant Ab (PeproTech, 200–01A), PARP Rabbit polyclonal Ab (Cell Signaling Tech, 9542S),

(6) The NLRP1 and CARD8 inflammasomes detect reductive stressCell reportsJanuary 31, 2023Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA.

(7) Oxidized thioredoxin-1 restrains the NLRP1 inflammasomeScience immunologyNovember 11, 2022Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, et al.anti-GSDMD (NBP2-33422, Novus), anti-mGSDMD (ab209845, Abcam) anti-IL-1β (AF201NA, R&D systems), anti-IL-18 (AF2548, R&D systems), IRDye 800CQ streptavidin (926-32230, LI-COR). Experiments involving Poly(I:C) were performed

(8) M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasomeNature chemical biologyMay 1, 2022Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, et al.

(9) Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activationAmerican journal of physiology. Renal physiologyFebruary 1, 2019Xu Y, Wang J, Xu W, Ding F, Ding W.(TOMM20; ab56783) (20) were obtained from Abcam (Cambridge, MA). Anti-IL-1␤ (AF-201-NA) and anti-IL-18 (AF2548) (27) goat polyclonal antibodies were purchased from R&D Systems (Minneapolis, MN). Cell culture and transfection

(10) DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosisNature chemical biologyJanuary 1, 2017Okondo MC, Johnson DC, Sridharan R, Go EB, Chui AJ, Wang MS, Poplawski SE, Wu W, Liu Y, Lai JH, et al.R&D Systems), mouse IL-1β (clone D4T2D, Cell Signaling Technology), IL-1α (#AF-200, R&D Systems), IL-18 (#AF2548, R&D Systems), GAPDH (clone 14C10, Cell Signaling Technology), DPP7 (Clone 398024, R&D Systems), DPP8

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IL-18/IL-1F4 Antibody

IL-18/IL-1F4 Antibody

IL-18/IL-1F4 Antibody

IL-18/IL-1F4 Antibody

IL-18/IL-1F4 Antibody

Human/Rhesus Macaque IL-18/IL-1F4 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

Reviews

Human/Rhesus Macaque IL-18/IL-1F4 Antibody from R&D Systems, a Bio-Techne Brand

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