Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb 4539S from Cell Signaling Technology

Product Specs
ItemPhospho-cdc2 (Tyr15) (10A11) Rabbit mAb
CompanyCell Signaling Technology
Price $462.00 Inquire
Catalog Number4539S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, M, R, Mk
TargetCdc2 (Tyr15) phosphate
ModificationsCdc2 (Tyr15) phosphate
HostRabbit
NCBI Gene AliasesCDC2, CDC28A, P34CDC2
ClonalityMonoclonal
NCBI Full Gene Namecyclin dependent kinase 1
Research AreaCell Cycle / Checkpoint Control
Clone10A11
Molecular Weight34

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle controlElifeMay 27, 2026Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, Matthew Cronin, Jason E Gestwicki, Shaeri Mukherjee,Cell Signaling Technology,28755S,WB (1:1000) Antibody,"Anti-phospho-CDK1(Y15) (rabbit, monoclonal)",Cell Signaling Technology,4539S,WB (1:1000) Antibody,"Anti-cyclin B (mouse, monoclonal)",Santa Cruz Biotechnology,sc-245,WB (1:500) Antibody,"Anti-phospho-histone-H3

(2) Exploring the mechanism of action of glaucocalyxin D against acute myeloid leukemia using network pharmacology, molecular docking and cellular experimentsOncology LettersApril 27, 2026Lian Chen, Weixian Yang, Weiqing Zhang, Heng Luo, Chen YanProteintech Group Inc.), anti-cyclin B1 (cat. no. 55004-1-AP; Proteintech Group Inc.), anti-p-CDK1 (Tyr15; cat. no. 4539; Cell Signaling Technology, Inc.) and anti-β-actin (anti-β-actin (cat. no. 66009-1-Ig; Proteintech Group Inc

(3) Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphomaCell Death & DiseaseMarch 23, 2026Wenqin Wang, Hui Zhou, Shuangxiong Tan, Dongmei Qin, Shuxuan Wang, Chunlan Xu, Xiangru Lei, Wenjuan Li, Liangjie Wang, Shuhui Fu, et al.(#3686; CST), Cyclin E1 (#11935-1-AP; Proteintech), CDK2 (#10122-1-AP; Proteintech), phospho-CDK2 (#4539; CST), GLUT1(#73015; CST), PGK1(A12686; ABclonal), β-Tubulin (#10094-1-AP; Proteintech), Lamin B1 (#13435;

(4) The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 PathwayDrug Des Devel TherMarch 16, 2026Lulin Zhu, Rong Dong, Gezi Yan, Haixin Zhu, Youyou Yan, Bo Zhang, Gang Wang, Nengming Lin, Biqin Tan(Cell Signaling Technology, Cat# 2348s), chk1 (Abcam, Cat# ab40866), p-cdc2 (Cell Signaling Technology, Cat# 4539s), cdc2 (Cell Signaling Technology, Cat# 9116s), γ-H2AX (Cell Signaling Technology, Cat# 9718s), cleaved

(5) The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 PathwayDrug Des Devel TherMarch 16, 2026Lulin Zhu, Rong Dong, Gezi Yan, Haixin Zhu, Youyou Yan, Bo Zhang, Gang Wang, Nengming Lin, Biqin Tan(Cell Signaling Technology, Cat# 2348s), chk1 (Abcam, Cat# ab40866), p-cdc2 (Cell Signaling Technology, Cat# 4539s), cdc2 (Cell Signaling Technology, Cat# 9116s), γ-H2AX (Cell Signaling Technology, Cat# 9718s), cleaved

(6) Targeting the splicing factor CWC22 induces mitotic slippage through repression of BubR1 expression and CDK1 activity in cancer cellsJournal of Biological ChemistryMarch 1, 2026Ryuzaburo Yuki, Youhei Saito, Yuji Nakayamadilution; sc-54, Santa Cruz Biotechnology), rabbit monoclonal anti-phospho-Cdc2 (Tyr-15) (1:500 dilution; #4539, Cell Signaling Technology), rabbit polyclonal anti-BUB1B (IB, 1:2000 dilution; 11504-2-AP, Proteintech Group, Inc

(7) Multi-omic analysis of human PHACTR1 signaling networksCommunications BiologyJanuary 19, 2026Kathryn Wolhuter, Lijiang Ma, Nicole S. Bryce, Osvaldo Contreras, Natalie Mellett, Ling Zhong, Chris Thekkedam, Siiri E. Iismaa, Corey Giles, Richard P. Harvey, et al.(Ser10, #53348), Cyclin A2 (#91500), Cyclin B1 (#12231), Cyclin E1 (#20808), Phospho-cdc2 (Tyr15, #4539), Tom20 (#42406), OPA1 (#80471), DRP1 (#8570), Phospho-DRP1 (Ser616, #4494), Phospho-DRP1 (Ser637, #6319),

(8) Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulationiScienceDecember 19, 2025Weiyu Wu, Ren Zhang, Geer Chen, Ziyu Chen, Zicong Lin, Yin Chen, Jiaqi Li, Weilin Liao, Junyi Wang, Xiaoxuan Wang, et al.,Cell Signaling Technology,Cat#9116; RRID: AB_2074795 anti-Phospho-CDC2 (Tyr15),Cell Signaling Technology,Cat#4539; RRID: AB_560953 anti-Cyclin B1,Cell Signaling Technology,Cat#12231; RRID: AB_2783553 anti-KEAP1,Cell Signaling Technology

(9) Narciclasine as a potential therapeutic agent to overcome EGFR-TKI resistance in non-small cell lung cancerJ Transl MedDecember 5, 2025Jee Young Sung, Ha-Eun Yoo, Soomi Kim, Suyeun Yu, Sang-Won Park, Ga-Eun Lim, Byung Il Lee, Kyungsil Yoon, Hyo Jung Kim, Sang-Ku Ye, et al.phospho-STAT3 Y705 (#9145, CST), phospho-Src (#6943,CST), total-Src (#2109, CST), phospho-CDK1 Y15 (#4539, CST), phospho-Wee1 (#4910, CST), Myt1 (#4282, CST), p21 (#2947, CST), Cdc25B (#9525, CST), GAPDH (#5174,

(10) The KIF18A Inhibitor ATX020 Induces Mitotic Arrest and DNA Damage in Chromosomally Instable High-Grade Serous Ovarian Cancer CellsCellsNovember 26, 2025Jayakumar Nair, Tzu-Ting Huang, Maureen Lynes, Sanjoy Khan, Serena Silver, Jung-Min Lee(#9701), histone H3 (HH3) (#14269), pKAP1-S824 (#4127), KAP1 (#5868), γH2AX-S139 (#9718), pCDK1-Y15 (#4539), CDK1 (#9116) and GAPDH (#2118) were obtained from Cell Signaling (Cell Signaling Technology, Denvers,

(11) WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress responseNature CommunicationsNovember 24, 2025Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael VanInsberghe, Marieke Everts, Femke J. Bakker, H. Rudolf de Boer, et al.rabbit anti-PERK (Cell Signaling, #5683), 1:1000 rabbit anti-phospho-cdc2 (CDK1) Tyr15 (Cell Signaling, #4539), 1:500 rabbit anti-ATF4 (Cell Signaling, #11815), 1:500 mouse anti-ATF4 (Cell Signaling, #97038), 1:500

(12) Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule (CP) on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verificationActa Biochimica et Biophysica SinicaNovember 1, 2025Shiyu Wang, Yinshuang Lai, Huijing Huang, Jing Yuan, Shanxin Li, Min Hui, Peipei Wang, Bingbing Chen, Zhiguo Liu, Jianchang Qian, et al.(Ser9) (5558), Cleaved PARP (Asp214) (5625), cyclin B1 (4138), c-Myc (5605), and Phospho-Cdc2 (Tyr15) (4539) were obtained from Cell Signaling Technology (Boston, USA). Antibodies against Phospho-PI3K (Tyr467/199)

(13) Coiled-coil interactions drive the ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cellsiScienceOctober 17, 2025Jason Tones, Jasper Jeffrey, Rachel M. Lackner, David M. Chenoweth, Huaiying Zhang611730) 1:100, Cdc2((POH1), Cell Signaling 9116) 1:300, Phospho-cdc2((Tyr15)(10A11), Cell Signaling 4539) 1:100, KNL1(generous gift from Iain Cheeseman) 1:1000. Following antibodies generously gifted from

(14) Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastomaiScienceSeptember 19, 2025Shuichiro Hirano, Atsuhito Uneda, Yoshihiro Otani, Yasuki Suruga, Ryoji Imoto, Madoka Hokama, Tsuyoshi Umeda, Ryosuke Ikemachi, Shohei Nishigaki, Nobushige Tsuboi, et al.following primary antibodies: anti-phospho-cdc2 (1:1000, Cell Signaling Technology, Danvers, MA, US, #4539), anti-Cyclin B1 (1:1000, Cell Signaling Technology, #12231), anti-phospho-Akt (Ser 473) (1:1000, Cell Signaling Technology

(15) A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damagebioRxivSeptember 11, 2025Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, Matthew Cronin, Jason E. Gestwicki, Shaeri Mukherjee(66031-1-Ig) Thymidine Kinase,1:1000,Cell Signaling Technology (28755S) pCdkl (Y15),1:1000,Cell Signaling Technology (4539S) Cyclin B,1:500,Santa Cruz Biotechnology (sc-245) pHistone H3 (S10),1:1000,Cell Signaling Technology

(16) Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activationNature CommunicationsSeptember 1, 2025Kamalakshi Deka, Jean-Michel Carter, Akash Bahai, Daniel Aron Ang, Nicholas Sim, Hooi Yan Chong, Guan Hwee Bernard Lee, Suet Mien Tan, Wee Joo Chng, Dennis Kappei, et al.santacruz), GAPDH (1:10000; sc-32233, santacruz), HA antibody (1:1000; sc-7392, Santacruz), pCDK1/2 (1:1000; 4539S, CST), CDK1/2 (1:500; sc-53219, santacruz), H3K27me3 (1:1000; 9733S, CST), H3 (1:1000; sc-517576, santacruz),

(17) G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytesProceedings of the National Academy of Sciences of the United States of AmericaAugust 26, 2025Waisertreiger I, Ayele K, Elshaikh MH, Barlow JH.A-11001; 1:200) were employed. Immunoblotting. Anti-phospho-CDC2 (Tyr15) (Cell Signaling Technology, 4539; 1:1,000), anti-CDC2 total (Cell Signaling Technology, 28439; 1:1,000), anti-β-Actin (ABclonal, AC026;

(18) Azenosertib Is a Potent and Selective WEE1 Kinase Inhibitor with Broad Antitumor Activity Across a Range of Solid TumorsMolecular Cancer TherapeuticsAugust 1, 2025Jianhui Ma, Wen Liu, Jiali Li, Daehwan Kim, Sangyub Kim, Alexandra Levy, Zhen Cai, Kevin D. Bunker, Alejandro Recio-Boiles, Jennifer M. Segar, et al.Primary antibodies were obtained from Cell Signaling Technology (CST) against phospho-CDK1 Y15 (CST, #4539 and #9111, RRID: AB_2074652), CDK1 (CST, #77055, RRID: AB_2716331), cyclin E1 (Abcam, #AB238081, RRID:

(19) Coiled-coil interactions drive ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cellsbioRxivJuly 31, 2025Jason Tones, Jasper Jeffrey, Rachel M. Lackner, David M. Chenoweth, Huaiying Zhang611730) 1:100, Cdc2((POH1), Cell Signaling 9116) 1:300, Phospho-cdc2((Tyr15)(10A11), Cell Signaling 4539) 1:100, KNL1(generous gift from Iain Cheeseman) 1:1000. Following antibodies generously gifted from

(20) Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancerCell Rep MedJuly 15, 2025Dongyang Tang, Shiqi Lin, Jingbo Zhou, Josh Haipeng Lei, Fangyuan Shao, Heng Sun, Xiangpeng Chu, Ling Li, Lin He, Yunfeng Qiao, et al.,Cell Signaling Technology,Cat#: 9116; RRID: AB_2074795 p-cdc2 (Tyr105),Cell Signaling Technology,Cat#: 4539; RRID: AB_560953 p21,Cell Signaling Technology,Cat#: 2947; RRID: AB_823586 AMPKα,Cell Signaling Technology,Cat#:

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Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb

Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb from Cell Signaling Technology

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