LATS2 (D83D6) Rabbit mAb 5888S from Cell Signaling Technology

Product Specs
ItemLATS2 (D83D6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5888S
Quantity100 µl
ApplicationsW
ReactivityH
TargetLATS2
HostRabbit
NCBI Gene AliasesKPM
ClonalityMonoclonal
NCBI Full Gene Namelarge tumor suppressor kinase 2
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneD83D6
Molecular Weight150

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctionsPLoS OneFebruary 2, 2026Chamika De Silva, Brian A. Kelch, Dannel McCollumantibodies (rabbit anti-LATS1 (1:500, Cell Signaling, 3477S), rabbit anti-LATS2 (1:500, Cell Signaling, 5888S), rabbit anti-LIMD1 (1:500, Novus biologicals, NBP2–56448), mouse anti-V5 (1:1000, Cell Signaling, 80076S)

(2) Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cellsPLOS BiologyJanuary 26, 2026Krupakar V. Subramaniam, Hui Jing Lim, Bao Wang, Valia T. Mihaylova, Evrett N. Thompson, Diane S. Krause, Ellen F. Foxman(Cell Signaling, #9157, 1:1,000), LATS1 (C66B5, Cell Signaling, #3477, 1:1,000), LATS2 (D83D6, Cell Signaling, #5888, 1:1,000), phospho-MST1 Thr183/MST2 Thr180 (Cell Signaling, #49332, 1:1,000), MST1 (Cell Signaling,

(3) Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAnessbioRxivOctober 24, 2025Madeleine Goldthorpe, Jiahui Hou, Abhi Nadendla, Hatice Ulku Osmanbeyoglu, Hun-Way HwangLATS1 (C66B5) Rabbit mAb (Cell Signaling Technology, 3477), LATS2 (D83D6) Rabbit mAb (Cell Signaling Technology, 5888). Reverse transcription and quantitative PCR (RT-qPCR) Quantitative PCR was performed using PerfeCTa

(4) Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctionsbioRxivSeptember 1, 2025Chamika De Silva, Brian A. Kelch, Dannel McCollum(TBST) and incubated overnight at 4°C with primary antibodies (rabbit anti-LATS2 (1:500, Cell Signaling, 5888S), mouse anti-V5 (1:1000, Cell Signaling, 80076S) or chicken anti-GFP (1:1000, Abcam, ab 13970)). Secondary

(5) HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancerClinical epigeneticsFebruary 26, 2025Lin TI, Tseng YR, Dong MJ, Lin CY, Chung WT, Liu CY, Tsai YF, Huang CC, Tseng LM, Chao TC, et al.(Cell Signaling Technology, Danvers, MA, USA, #3477), and LATS2 (Cell Signaling Technology, Danvers, MA, USA, #5888), with dilutions from 1:500 to 1:3000 in each blocking buffer. After primary antibody incubation with

(6) ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3Nat CommunFebruary 6, 2025Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, et al.(1:1000, Cell Signalling Technology, 3477, C66B5), anti-LATS2 (1:1000, Cell Signalling Technology, 5888, D83D6), anti-pLATS1T1079 (1:1000, Cell Signalling Technology, 8654, D57D3), anti-pLATS1S909 (1:1000,

(7) Melanoma cell line-derived exosomal miR-424-5p: a key promoter of angiogenesis through LATS2 interactionOncology ResearchJanuary 16, 2025JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG(Cell Signaling Technology, Danvers, MA, USA, #72312); LATS2 (Cell Signaling Technology, Danvers, MA, USA, #5888); Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) (Cell Signaling Technology, Danvers, MA, USA, #92310);

(8) Gene therapy for diffuse pleural mesotheliomas in preclinical models by concurrent expression of NF2 and SuperHippoCell reports. MedicineOctober 15, 2024Zhu R, Liu X, Zhang X, Zhong Z, Qi S, Jin R, Gu Y, Wang Y, Ling C, Chen K, et al.,Cell Signaling Technology,Cat#3477S; RRID: AB_2133513 Rabbit monoclonal anti-LATS2(D83D6),Cell Signaling Technology,Cat#5888S; RRID: AB_10835233 Rabbit monoclonal anti-SAV1(D6M6X),Cell Signaling Technology,Cat#13301S; RRID: AB_2798176 Mouse

(9) Hippo signaling pathway regulates Ebola virus transcription and egressNature CommunicationsAugust 13, 2024Jingjing Liang, Marija A. Djurkovic, Carson G. Leavitt, Olena Shtanko, Ronald N. HartyThe anti-myc monoclonal antibody (05-724) was from EMD Millipore. The anti-LATS1 (3477), anti-LATS2 (5888), and the anti-pSer127-YAP (13008) monoclonal antibodies were from Cell Signaling Technology. The secondary

(10) Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stressiScienceJune 21, 2024Xiaomin Cai, Christopher Warburton, Olivia F. Perez, Ying Wang, Lucy Ho, Christina Finelli, Quinn T. Ehlen, Chenzhou Wu, Carlos D. Rodriguez, Lee Kaplan, et al.AB_10971635 LATS1,Cell Signaling Technology,Cat# 3477; RRID: AB_2133513 LATS2,Cell Signaling Technology,Cat# 5888; RRID: AB_10835233 p-YAP(S127),Cell Signaling Technology,Cat# 13008; RRID: AB_2650553 pS176/180 IKK,Cell Signaling Technology

(11) Targeting miR‐31 represses tumourigenesis and dedifferentiation of BRAFV600E‐associated thyroid carcinomaClinical and Translational MedicineMay 26, 2024Peitao Zhang, Lizhao Guan, Wei Sun, Yu Zhang, Yaying Du, Shukai Yuan, Xiaolong Cao, Zhengquan Yu, Qiang Jia, Xiangqian Zheng, et al.(#8178S; CST), p65 (#8242; CST), p‐p65 (#3033; CST), AKT (#4691; CST), p‐AKT (#4060; CST), LATS2 (#5888; CST), ERK1/2 (#4695; CST), p‐ERK1/2 (#4370; CST), p38 (#8690; CST), p‐p38 (#4511; CST), BRAF (#14814;

(12) YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasiaiScienceMarch 15, 2024Zhifu Liu, Senmao Li, Shengbin Chen, Jindong Sheng, Zheng Li, Tianjing Lv, Wei Yu, Yu Fan, Jinlong Wang, Wei Liu, et al.RRID:AB_2744528 LATS1,Cell Signaling Technology,Cat#3477; RRID:AB_2133513 LATS2,Cell Signaling Technology,Cat#5888; RRID:AB_10835233 Phospho-LATS1 (Ser909),Cell Signaling Technology,Cat#9157; RRID:AB_2133515 MST1,Cell Signaling Technology

(13) KLF15 transcriptionally activates LINC00689 to inhibit colorectal cancer developmentCommunications biologyJanuary 25, 2024Cao Y, Li J, Zhang G, Fang H, Du Y, Liang Y.used: anti-KLF15 (1:2000, ab2647, Abcam), anti-PTBP1 (1:5000, ab133734, Abcam), anti-LATS2 (1:1000, #5888, Cell Signaling Technology), anti-CTGF (1:1000, ab209780, Abcam), anti-CYR61 (1:2000, ab228592, Abcam),

(14) Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axisNature communicationsJanuary 2, 2024Yang Y, Zhou H, Huang X, Wu C, Zheng K, Deng J, Zheng Y, Wang J, Chi X, Ma X, et al.#4911, 1:1000), p-MOB T35 (also used to detect p-Mats, CST #3863, 1:1000), LATS1/2 (CST #3477, CST #5888, 1:1000), cleaved Dcp-1 (CST #9578, 1:200) and GFP (CST #2956, 1:1000); p-TAOK2 S181 (also used to detect

(15) GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancyBiology directJanuary 2, 2024Li L, Tang J, Cao B, Xu Q, Xu S, Lin C, Tang C.normal mouse IgG (sc-2025) were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). LATS1 (#3477), LATS2 (#5888), phospho-YAP (pYAP-Ser127, #13008), YAP (#14074), TAZ (#72804) antibodies, and normal rabbit IgG (#2729)

(16) Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathwayCell Death & DiseaseNovember 27, 2023Ming-Qi Yan, Bing-Hong Zhu, Xiao-Hong Liu, Yu-Meng Yang, Xiu-Yun Duan, Yong Wang, Hui Sun, Mei Feng, Tao Li, Xiao-Man Liu,Cell Signaling Technology,3477,WB: 1:1000,Rabbit monoclonal LATS2,AB_10835233,Cell Signaling Technology,5888,WB: 1:1000,Rabbit monoclonal MIGA2 (FAM73B),AB_11129174,Abcam,ab122713,WB: 1:1000; IHC: 1:200; IP:

(17) The TGFβ→TAK1→LATS→YAP1 Pathway Regulates the Spatiotemporal Dynamics of YAP1Molecules and CellsOctober 31, 2023Min-Kyu Kim, Sang-Hyun Han, Tae-Geun Park, Soo-Hyun Song, Ja-Youl Lee, You-Soub Lee, Seo-Yeong Yoo, Xin-Zi Chi, Eung-Gook Kim, Ju-Won Jang, et al.(Cat No. 5694S), EZH2 (Cat No. 5246S), p-TAK1 (Cat No. 4508), LATS1 (Cat No. 3477), LATS2 (Cat No. 5888), p-LATS (Cat No. 9157), MST1 (Cat No. 14946), and p-MST1 (Cat No. 49332) were obtained from Cell Signaling Technology

(18) YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasisNature CommunicationsSeptember 22, 2023Zhengming Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Engler, Shenghong Ma, Qingquan Li, Kun-Liang Guan(Santa Cruz, #sc-251), GAPDH (Santa Cruz, #sc-47724), LATS1 (Cell signaling, #3477), LATS2 (Cell signaling, #5888), p-LATS (Cell signaling, #8654), H3 (Cell signaling, #4499), H3K27ac (Cell signaling, #8173), H3K4me3

(19) YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinomaThe Journal of clinical investigationMarch 1, 2023Frost TC, Gartin AK, Liu M, Cheng J, Dharaneeswaran H, Keskin DB, Wu CJ, Giobbie-Hurder A, Thakuria M, DeCaprio JA.anti-LATS1 (Cell Signaling Technology, 3477); 1:1,000 rabbit anti-LATS2 (Cell Signaling Technology, 5888); 1:1,000 rabbit anti-MST1 (Cell Signaling Technology, 3682); 1:1,000 rabbit anti-MST2 (Cell Signaling Technology

(20) Platycodin D confers oxaliplatin Resistance in Colorectal Cancer by activating the LATS2/YAP1 axis of the hippo signaling pathwayJournal of CancerJanuary 1, 2023Wang CH, Baskaran R, Ng SS, Wang TF, Li CC, Ho TJ, Hsieh DJ, Kuo CH, Chen MC, Huang CY.performed using ImageJ software (version 1.4.3.67) (NIH, Bethesda, MD, USA). Antibodies details: LATS2 (#5888, Cell Signaling, Baltimore, MD, USA), p-LATS2 (ab111344, Abcam, Cambridge, UK), YAP (sc-101199, Santa Cruz Biotechnology

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LATS2 (D83D6) Rabbit mAb

LATS2 (D83D6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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LATS2 (D83D6) Rabbit mAb from Cell Signaling Technology

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