Brd2 (D89B4) Rabbit mAb 5848S from Cell Signaling Technology

Product Specs
ItemBrd2 (D89B4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5848S
Quantity100 µl
ApplicationsW, W-S, ChIP, ChIP-seq, C&R
ReactivityH, M
TargetBRD2
HostRabbit
NCBI Gene AliasesBRD2-IT1, D6S113E, FSH, FSHRG1, FSRG1, NAT, O27.1.1, RING3, RNF3
ClonalityMonoclonal
NCBI Full Gene Namebromodomain containing 2
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD89B4
Molecular Weight110

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) BRD4 regulation of PIM1 identifies a novel therapeutic vulnerability in acute megakaryoblastic leukemiaCancer Cell InternationalJune 17, 2026Ailian Guo, Fang Fang, Peifang Xiao, Linbo Cai, Gen Li, Yang Yang, Zimu Zhang, Yanfang Tao, Li Gao, Zhizhuo Du, et al.MA, USA), anti-PARP (9542 S, CST, MA, USA), anti-GAPDH (AP0063, Bioworld Technology Inc.), anti-BRD2 (5848 S, CST, MA, USA), anti-BRD3 (11859-1-AP, Proteintech, IL, USA), anti-BRD4 (13440 S, CST, MA, USA), anti-C-Myc

(2) BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibitionCellular & Molecular Biology LettersMay 2, 2026Suyakarn Archasappawat, Juliette Jacques, EunJung Lee, Chang-il Hwangwas incubated overnight at 4 °C with constant rotation with 10 µl of BRD2 (Cell Signaling Technology, 5848S) or BRD4 (Bethyl, A301-985A100) antibody per reaction. Bead capture, washes, elution, reverse crosslinking,

(3) Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 DegradersJournal of Medicinal ChemistryApril 9, 2026Hiroyuki Yamakoshi, Ryo Watanabe, Ryosuke Segawa, Ryosuke Ishihara, Ryo Tachibana, Genki Kudo, Shota Nagasawa, Satoshi Yamanaka, Ayano Ito, Hiroyuki Takeda, et al.Danvers, MA, USA; 1:1000), BRD3 (#sc-81202, Santa Cruz Biotechnology, Dallas, TX, USA; 1:500), or BRD2 (#5848, Cell Signaling Technology; 1:1000). HRP-conjugated antirabbit IgG (#7074, Cell Signaling Technology;

(4) Charged molecular glue discovery enabled by targeted degron displayNature Chemical BiologyApril 6, 2026Zhe Zhuang, Woong Sub Byun, Jakub Chrustowicz, Zuzanna Kozicka, Veronica L. Li, Dinah M. Abeja, Katherine A. Donovan, Sara Sepic, Inchul You, Mikołaj Słabicki, et al.Cell Signaling Technology), anti-BRD3 (ab50818, Abcam), anti-α-tubulin (3873, Cell Signaling Technology), anti-BRD2 (5848, Cell Signaling Technology), anti-c-Myc (5605, Cell Signaling Technology), anti-YPEL5 (PA5-26957, Invitrogen),

(5) CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1StructureMarch 20, 2026Kankan Wang, Sebastian Kenny, Zhana Chagan, Lihong Li, Chittaranjan Das, Xing Liuanti-ZFP91,Bethyl Laboratories,Cat # A303–245A; RRID: AB_10953803 Rabbit anti-BRD2,Cell Signaling Technology,Cat # 5848; RRID: AB_10835146 Rabbit anti-CAND1,Bethyl Laboratories,Cat # A302–901A; RRID: AB_10663486 Rabbit

(6) Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine FibroidsInt J Mol SciDecember 17, 2025Qiwei Yang, Somayeh Vafaei, Ali Falahati, Azad Khosh, Mervat M. Omran, Tao Bai, Maria Victoria Bariani, Mohamed Ali, Thomas G. Boyer, Ayman Al-HendyAssay kit) (Bio-Rad Laboratories, Inc., Hercules, CA, USA). The primary antibodies, including BRD2 (5848, 1:1000 dilution, Cell Signaling Technology, Danvers, MA, USA), BRD3 (ab50818, 1:1000 dilution, Abcam,

(7) A triple-action PROTAC for wild-type p53 cancer therapyCell Reports MedicineDecember 16, 2025Gregory H. Bird, Utsarga Adhikary, Michael J. Schmidt, Marina Godes, Bethany Tesar, Christina M. Camara, Joao A. Paulo, Julia F. Vidlak, Thomas M. DeAngelo, Marilyn Marquez, et al.#13440, RRID: AB_2687578]; BRD3 [Cell Signaling Technology, #94032]; BRD2 [Cell Signaling Technology, #5848, RRID: AB_10835146]). The membranes were then washed with PBS-T and treated with secondary HRP-conjugated

(8) High-throughput in silico screen uncovers key regulators of 3D genome architecturebioRxiv : the preprint server for biologyDecember 11, 2025Bai J, Lyu Q, Tan J, Issner R, Tischer B, Liu H, Goel V, Ling X, Bernstein BE, Tsirigos A, et al.(abcam, ab9263), STAG1 (abcam, ab4457), STAG2 (abcam, ab4464), BRD2 (Cell Signaling Technology Inc, # 5848), BRD4 (GeneTex, Inc, GTX130586), Goat IgG Isotype Control (ThermoFisher, 31245), Mouse IgG Isotype Control

(9) BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastomaNeuro-OncologyNovember 1, 2025Raghavendra Vadla, Brett Taylor, Yohei Miyake, Benjamin Lin, Daisuke Kawauchi, Shunichiro Miki, Nidhi Nathwani, Brandon M Jones, Yashpreet Kaur, Abhinaba Banerjee, et al.in RIPA buffer. The following antibodies were used, anti-BRD2 (Cell Signaling Technologies (CST), #5848), anti-RelA/p65 (CST, #8242), anti-BRD4 (CST, #13440), anti-GAPDH (CST, #2118), anti-TBP (CST, #44059),

(10) BRD2 Upregulation as a Pan-Cancer Adaptive Resistance Mechanism to BET InhibitionbioRxivSeptember 11, 2025Suyakarn Archasappawat, Juliette Jacques, EunJung Lee, Chang-il HwangFor immunoprecipitation, 10 μl of antibody was used per reaction: BRD2 (Cell Signaling Technology, 5848S) or BRD4 (Bethyl Laboratories, A301-985A100). Chromatin and protein G magnetic beads were incubated

(11) Overcoming BET ‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2 – FTH1 axisThe FEBS JournalJuly 13, 2025Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Fanielloanti‐FTH1 (Santa Cruz Biotechnology, Dallas, TX, USA, sc‐376594), anti‐BRD2 (Cell signaling Technology, #5848S), anti‐BRD4 (Thermo Fisher Scientific, PA5‐100998). After three washes, secondary antibody (anti‐mouse

(12) Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein DegradationJournal of Medicinal ChemistryApril 24, 2025Zhijie Deng, Jerrel Catlett, Youngeun Lee, Qiong Wu, Zhongli Xu, Ling Xie, Xian Chen, Yan Xiong, H. Ümit Kaniskan, Jian Jin(Bio-Rad Laboratories). The following primary antibodies (1:1000 dilution) were used in this study: BRD2 (5848S, Cell Signaling Technology [CST]), BRD3 (ab50818, Abcam), BRD4 (ab128874, Abcam), c-MYC (5605S, CST),

(13) Ectopic expression of testis-specific transcription elongation factor in driving cancerSci AdvMarch 14, 2025Bin Zheng, Marta Iwanaszko, Shimaa Hassan AbdelAziz Soliman, Yukitomo Ishi, Sarah Gold, Ruxuan Qiu, Benjamin Charles Howard, Madhurima Das, Zibo Zhao, Rintaro Hashizume, et al.sample buffer was added. Samples were then boiled for 5 min for Western blot. BRD4 (#13440), BRD2 (#5848), β-actin (#3700), CDK9 (#2316), BRD3 (#94032), and cyclin T1 (#81464) antibodies were purchased from

(14) Discovery of electrophilic degraders that exploit SNAr chemistrybioRxivSeptember 27, 2024Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang, Hannah M. Jones, Dinah M. Abeja, Meredith N. Nix, Jianing Zhong, et al.Cell Signaling Technology), anti-BRD1 (cat. no. sc-398226; Santa Cruz Biotechnology, Dallas, TX, USA), anti-BRD2 (cat. no. 5848; Cell Signaling Technology, Danvers, MA, USA), anti-phospho-Rpb1 CTD (Ser2) (cat. no. 04–1571; Sigma-Aldrich),

(15) BRD7 as key factor in PBAF complex assembly and CD8+ T cell differentiationJCI InsightAugust 8, 2024Feng Huang, Yingtong Lin, Yidan Qiao, Yaochang Yuan, Zhihan Zhong, Baohong Luo, Yating Wu, Jun Liu, Jingliang Chen, Wanying Zhang, et al.Inc.), BRG1 rabbit mAb (1:500, D1Q7F, 49360, Cell Signaling Technology), BRD2 rabbit mAb (1:500, D89B4, 5848, Cell Signaling Technology), BRD4 rabbit mAb (1:500, E2A7X, 13440, Cell Signaling Technology), TRIM28

(16) The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcomaBMC CancerAugust 1, 2024Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, et al.13440, RRID: AB_2687578), Ki67(Abcam Cat# ab16667, RRID: AB_302459), BRD2(Cell Signaling Technology Cat# 5848, RRID: AB_10835146), BRD3(Proteintech Cat# 11859-1-AP, RRID: AB_2065902), PARP(Cell Signaling Technology

(17) Intrinsic signaling pathways modulate targeted protein degradationNature CommunicationsJuly 2, 2024Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, et al.for western blotting: anti-BRD4 (Cell Signaling Technology, #13440), anti-BRD2 (Cell Signaling Technology, #5848), anti-BRD3 (Santa Cruz Biotechnology, sc-515666), anti-PAR (Cell Signaling Technology, #83732), anti-TRIP12

(18) MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastomaBMC CancerFebruary 16, 2024Gen Li, Liya Ma, Chenxi Feng, Hongli Yin, Jianping Bao, Di Wu, Zimu Zhang, Xiaolu Li, Zhiheng Li, Chun Yang, et al.units/ml streptomycin, and 100 μg/ml penicillin. The primary antibodies against BRD4 (13440S), BRD2 (5848S), PARP (9542S), VHL (68547S), GAPDH (5174S) were purchased from Cell Signaling Technology (USA), Ki-67

(19) CAND1 inhibits Cullin-2-RING ubiquitin ligases for enhanced substrate specificityNature structural & molecular biologyFebruary 1, 2024Wang K, Diaz S, Li L, Lohman JR, Liu X.sc-135895, 1:500 dilution), anti-ELOB (Bethyl Laboratories # A304-008A), anti-BRD2 (Cell Signaling # 5848), anti-BRD3 (Abcam # ab50818, 1:500 dilution), anti-BRD4 (Abcam # ab128874), anti-FLAG (Sigma-Aldrich

(20) Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin ComplexbioRxivOctober 5, 2023Raghavendra Vadla, Shunichiro Miki, Brett Taylor, Daisuke Kawauchi, Brandon M Jones, Nidhi Nathwani, Philip Pham, Jonathan Tsang, David A. Nathanson, Frank B. FurnariChemiDoc MP system (Bio-Rad). The following antibodies were used, anti-BRD2 (Cell Signaling Technology, #5848), anti-RelA/p65 (Cell Signaling Technology, #8242), anti-BRD4 (Cell Signaling Technology, #13440), anti-GAPDH

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Brd2 (D89B4) Rabbit mAb

Brd2 (D89B4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Brd2 (D89B4) Rabbit mAb from Cell Signaling Technology

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