Apaf-1 (D7G4) Rabbit mAb 8723S from Cell Signaling Technology

Product Specs
ItemApaf-1 (D7G4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8723S
Quantity100 µl
ApplicationsW
ReactivityH, M, R
TargetAPAF
IsotypeIgG
HostRabbit
NCBI Gene AliasesAPAF-1, CED4
NCBI Full Gene Nameapoptotic peptidase activating factor 1
CloneD7G4
Molecular Weight135
ClonalityMonoclonal
Research AreaApoptosis

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Mechanism of Astragaloside IV Against Cerebral Ischemia–Reperfusion Injury: Inhibiting Neuronal Apoptosis via the CytC/Apaf-1 Mitochondrial PathwayPharmaceuticals (Basel)March 29, 2026Tongtong He, Zhe Zhang, Xiaohong Zhou, Ping Gao, Zhenyi Liu, Yanmeng Zhao, Hua Liang, Weijuan Gao, Xiaofei JinBatch No.: HY-100472. Antibodies were sourced from multiple vendors: The Apaf-1 antibody (Cat. No.: 8723) was obtained from Cell Signaling Technology, Inc. (Boston, MA, USA); CytC antibody (Cat. No.: 10993-1-AP)

(2) tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosisiScienceMarch 21, 2025Ni Yin, Xian Xie, Dan Li, Shikun Yang, Yan Liu, Yongzhong Tang, Hao Zhang, Wei ZhangRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Rabbit monoclonal anti-Apaf1,Cell Signaling Technology,Cat#8723; RRID: AB_3676010 Rabbit monoclonal anti-Apaf1,Beyotime,Cat#AF1462; RRID: AB_3676027 Rabbit polyclonal

(3) B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosisFrontiers in PharmacologyJune 28, 2024Krishnapriya M. Varier, Gou Dan, Xiaolong Li, Wuling Liu, Fei Jiang, Ke-Gang Linghu, Yanmei Li, Yaacov Ben-David, Nenling Zhang, Chaoda Xiao, et al.(SA00001-2) were purchased from Proteintech (US). The antibodies Cleaved-caspase3 (#9661), APAF-1 (#8723), and Cleaved-caspase9 (#9505) were obtained from Cell Signalling Technology (CST, US). The GAPDH (AP0063),

(4) Antitumor effect of <italic>Escherichia coli</italic>-derived outer membrane vesicles on neuroblastoma <italic>in vitro</italic> and <italic>in vivo</italic>Acta Biochimica et Biophysica SinicaSeptember 25, 2022Liming Jin, Zhaoxia Zhang, Xiaojun Tan, Zhaoying Wang, Bo Tang, Zhang Wang, Mujie Li, Tao Mi, Lianju Shen, Chunlan Long, et al.BCL-2 and cleaved caspase-3, Cyt c, P21 and APAF (1:1000; #2772, #15071, #9661, #11940, #2947, and #8723); Cell Signaling Technology, Beverly, USA); MMP-2, PCNA, N-myc, GAPDH and VDAC1 (1:1000; 380817, 200947-2E1,

(5) A ROS-responsive, self-immolative and self-reporting hydrogen sulfide donor with multiple biological activities for the treatment of myocardial infarctionBioactive materialsMarch 1, 2022Yao M, Lu Y, Shi L, Huang Y, Zhang Q, Tan J, Hu P, Zhang J, Luo G, Zhang N.Phospho-Stat1 (#7649, dilution 1:1000), antibody to p53 (#32532, dilution 1:1000), antibody to Apaf-1 (#8723, dilution 1:1000), and antibody to GAPDH (#2118, dilution 1:1000) were purchased from Cell Signaling Technology

(6) Secretory Autophagosomes from Alveolar Macrophages Exacerbate Acute Respiratory Distress Syndrome by Releasing IL-1βJournal of inflammation researchJanuary 1, 2022Xu X, Liu X, Dong X, Qiu H, Yang Y, Liu L.antibodies against LC3B, Beclin-1, Rab8a, Apaf-1, CD40L, and β-actin (1:1000 for all; #43566, #3495, #6975, #8723, #15094, and #4970, respectively, Cell Signaling Technology), and CD63 (1:1000, 25682–1-AP, Proteintech).

(7) NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in miceScience AdvancesOctober 22, 2021Peipei Zhang, Yifei Liu, Lichen Hu, Kai Huang, Mao Hong, Yuze Wang, Xinrui Fan, Richard J. Ulevitch, Jiahuai Hanpro–caspase-8 (4790, Cell Signaling Technology), cleaved caspase-8 (9429, Cell Signaling Technology), Apaf1 (8723, Cell Signaling Technology), caspase-9 (9508, Cell Signaling Technology), GSDMD (ab209845, Abcam), ASC

(8) A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5PLoS biologyAugust 1, 2021Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, et al.anti-rabbit antibody (Invitrogen, A11034). Antibodies for western blot: Apaf-1 (Cell Signaling Technology, 8723S); caspase-3 (Cell Signaling Technology, 9662); caspase-1 (clone 4B4, a kind gift from Dr. Vishva M.

(9) Costunolide attenuates oxygen‑glucose deprivation/reperfusion‑induced mitochondrial‑mediated apoptosis in PC12 cellsMolecular Medicine ReportsMarch 30, 2021Lanqing Meng, Huixia Ma, Jinni Meng, Tingting Li, Yafei Zhu, Qipeng Zhaoantibody (cat. no. ZB-2301). Primary antibodies against α-tubulin (cat. no. 2148), Apaf-1 (cat. no. 8723), Bcl-2 (cat. no. 2876) and Bax (cat. no. 2772) were provided by Cell Signaling Technology, Inc. Antibodies

(10) Abnormal expression of TRIAP1 and its role in gestational diabetes mellitus-related pancreatic β cellsExperimental and therapeutic medicineMarch 1, 2021Li L, Yang K, Ye F, Xu Y, Cao L, Sheng J.primary antibodies: TRIAP1 (cat. no. 515801; 1:1,000; Santa Cruz Biotechnology, Inc.), APAF1 (cat. no. 8723; 1:1,000; Cell Signaling Technology, Inc.), caspase-3 (cat. no. 14220; 1:1000; Cell Signaling Technology,

(11) Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal ApoptosisInternational journal of molecular sciencesMay 24, 2020Sabirzhanov B, Makarevich O, Barrett J, Jackson IL, Faden AI, Stoica BA.serine/threonine kinase (Phospho-ATR) (Ser428) (#2853), Cleaved Caspase-3 (#9661), PARP (#9542), Apaf-1 (#8723), phospho-p53 (Ser15) (#9284), PUMA (#14570), p53 (#2524), Phospho-Akt (Ser473) (#4060; Cell Signaling Technology

(12) Novel peptide dermaseptin-PS1 exhibits anticancer activity via induction of intrinsic apoptosis signallingJournal of cellular and molecular medicineFebruary 1, 2019Long Q, Li L, Wang H, Li M, Wang L, Zhou M, Su Q, Chen T, Wu Y.#9746), FADD (Cell Signalling; #2782), caspase 9 (Cell Signalling; #9508), Apaf‐1 (Cell Signalling; #8723), Bcl‐2 (Cell Signalling; #4223), Bax (Cell Signalling; #5023), Bak (Cell Signalling; #3814), Bad (Cell Signalling

(13) Exogenous expression of miRNA-3613-3p causes APAF1 downregulation and affects several proteins involved in apoptosis in BE(2)-C human neuroblastoma cellsInternational Journal of OncologyJuly 31, 2018Iwona Nowak, Elżbieta Boratyn, Małgorzata Durbas, Irena Horwacik, Hanna RokitaAnti‑DICER rabbit monoclonal antibody (mAb) (cat. no. 5362, 1:1,000); anti‑APAF1 rabbit mAb (cat. no. 8723, 1:1,000); anti‑caspase-9 mouse mAb (cat. no. 9508, 1:1,000); anti‑cleaved caspase-9 rabbit mAb (cat. no.

(14) Stable STIM1 Knockdown in Self-Renewing Human Neural Precursors Promotes Premature Neural DifferentiationFrontiers in Molecular NeuroscienceJune 11, 2018Renjitha Gopurappilly, Bipan Kumar Deb, Pragnya Chakraborty, Gaiti Hasan

(15) Protective effects of dehydrocostuslactone on rat hippocampal slice injury induced by oxygen‑glucose deprivation/reoxygenationInternational Journal of Molecular MedicineMay 17, 2018Qipeng Zhao, Ailing Chen, Xiaobo Wang, Zhuanzhuan Zhang, Yunsheng Zhao, Yu Huang, Shuanglai Ren, Yafei Zhuprimary antibodies against Bcl‑2 (cat. no. 2876), Bax (cat. no. 2772), cyt‑c (cat. no. 4272), apaf‑1 (cat. no. 8723) and β‑actin (cat. no. 4970) were obtained from Cell Signaling Technology, Inc., (Danvers, MA, USA);

(16) Rb is required for retinal angiogenesis and laminationCell death & diseaseMarch 6, 2018Zhou Y, Wei R, Zhang L, Chen Y, Lu S, Liang C, Wang Y, Xiao L, Zhang J, Bremner R, et al.

(17) Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortexScientific ReportsDecember 1, 2017Jihane Homman-Ludiye, William C. Kwan, Mitchell J. de Souza, Jennifer Rodger, James A. Bourne

(18) Decreased hippocampal brain-derived neurotrophic factor and impaired cognitive function by hypoglossal nerve transection in ratsJournal of Cellular and Molecular MedicineDecember 1, 2017Doyun Kim, Sena Chung, Seung-Hyun Lee, Se-Young Choi, Soung-Min Kim, JaeHyung Koo, Jong-Ho Lee, Jeong Won Jahng

(19) Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent ApoptosisScientific reportsSeptember 12, 2017Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.purchased as follows: from Cell Signaling Technology, primary antibodies against AIF (#4642), Apaf-1 (#8723), ATF-4 (#11815), Bax (#2772), Bcl-2 (#2876), Caspase-9 (#9502), CHOP (#2895), COX IV (#4844), LC3A/B

(20) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiencyNature cell biologySeptember 1, 2017Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, et al.(32023, Abcam, 1/1000 dilution), anti-STING (13467S, Cell Signalling, 1/1000 dilution), anti-APAF-1 (8723, Cell Signalling, 1/500 dilution), anti-NFκB-p65 (8242P, Cell Signalling, 1/1000 dilution), anti-p100/p52

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Apaf-1 (D7G4) Rabbit mAb

Apaf-1 (D7G4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Apaf-1 (D7G4) Rabbit mAb from Cell Signaling Technology

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