Presenilin 2 (D30G3) Rabbit mAb 9979S from Cell Signaling Technology

Product Specs
ItemPresenilin 2 (D30G3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number9979S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetPresenilin-2
HostRabbit
NCBI Gene AliasesAD3L, AD4, CMD1V, PS2, STM2
ClonalityMonoclonal
NCBI Full Gene Namepresenilin 2
Research AreaNeuroscience
IsotypeIgG
CloneD30G3
Molecular Weight23 (CTF)

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease ModelbioRxivSeptember 16, 2025Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Mohammed Repon Khan, Justin Wang, Lauren Guttman, Devanik Biswas, Abhishek Pasupuleti, Akansha Aggarwal, Shraddha Pandya, et al.,Thermo Fisher Scientific "PSEN1 (D39D1, Rabbit mAb)",5643,Cell Signaling Technology "PSEN2 (D30G3, Rabbit mAb)",9979,Cell Signaling Technology NEP2,AB5458,Millipore IDE,921203,BioLegend β-Actin–Peroxidase (Mouse mAb),A3854,Sigma-Aldrich IBA1,ab5076,Abcam GFAP,ab7260,Abcam Aβ

(2) Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysisMol NeurodegenerJune 20, 2025Oliver J. Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, et al.A8717,RRID: AB_258409 PSEN1,rat,Millipore MAB1563,RRID: B_11215630 PSEN2,rabbit,Cell Signalling Technology 9979,RRID: AB_10829910 Actin,mouse,Sigma A1978,RRID: AB_476692 GAPDH,mouse,Ambion AM4300,RRID: AB_437392 sAPPβ,rabbit,IBL

(3) Tunneling nanotube–like structures regulate distant cellular interactions during heart formationScienceMarch 14, 2025Lianjie Miao, Yangyang Lu, Anika Nusrat, Guizhen Fan, Shaohua Zhang, Luqi Zhao, Chia-Ling Wu, Hongyan Guo, Trang Le Nu Huyen, Yi Zheng, et al.Abcam, ab7280), Presenilin 1 (1:1000, Cell signaling, 5643), Presenilin 2 (1:1000, Cell signaling, 9979), PEN2 (1:1000, Cell signaling, 8598), p-Akt (1:1000, Cell Signaling Technology, 9271S), p-Erk (1:1000,

(4) PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s diseaseActa Neuropathologica CommunicationsOctober 21, 2024Florian Perrin, Lauren C. Anderson, Shane P. C. Mitchell, Priyanka Sinha, Yuliia Turchyna, Masato Maesako, Mei C. Q. Houser, Can Zhang, Steven L. Wagner, Rudolph E. Tanzi, et al.(Biolegends, 823,401), mouse anti-β-actin (A2228, Sigma-Aldrich, St. Louis, MO); rabbit anti-PS2 (mAb 9979, Cell Signaling Technology, Danvers, MA); EGFR (ab52894, Abcam, MA); normal rabbit IgG (2728S, Cell Signaling Technology

(5) The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestationsAlzheimer's & DementiaJuly 1, 2024Charles Arber, Christopher R. S. Belder, Filip Tomczuk, Rebecca Gabriele, Yazead Buhidma, Clíona Farrell, Antoinette O'Connor, Helen Rice, Tammaryn Lashley, Nick C. Fox, et al.Millipore MAB348 RRID:AB_94882; APP ctf Thermo A8717 RRID:AB_258409; PSEN2 Cell Signalling Technology 9979 RRID:AB_10829910; and Actin Sigma A1978 RRID:AB_476692. 2.9 Aβ ELISAs Media was harvested after 48

(6) Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathyiScienceJanuary 19, 2024Saito J, Dave JM, Lau FD, Greif DM.anti-PSEN-1 (Cell Signaling Technology, 5643; 1:150), rabbit anti-PSEN-2 (Cell Signaling Technology, 9979; 1:250), rabbit anti-HES1 (Cell Signaling Technology, 11988; 1:1000), rabbit anti-HEY1 (Abcam, ab235173;

(7) Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1The Journal of biological chemistryAugust 1, 2023Kurth V, Ogorek I, Münch C, Lopez-Rios J, Ousson S, Lehmann S, Nieweg K, Roebroek AJM, Pietrzik CU, Beher D, et al.5451); anti-PSEN2 (rabbit mAb clone D30G3, immunoblotting: 1:1,000, Cell Signaling Technology Cat. No. 9979); anti-BACE1 (rabbit mAb clone D10E5, immunoblotting: 1:1,000, Cell Signaling Technology Cat. No. 5606);

(8) Selective inhibitors of the PSEN1–gamma-secretase complexJournal of Biological ChemistryJune 1, 2023Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez-Benito, Marti Municoy, Victor Guallar, Dries T’Syen, Maarten Dewilde, François Bischoff, Erwin Fraiponts, Gary Tresadern, et al.in mouse and B82, B78, and B126 against APH1A, APH1B, PSENEN, respectively (62), 1/1000 and PSEN2 (9979, Cell signaling Technology), 1/1000 raised in rabbit. Alignment of known Psen1 selective inhibitors The

(9) Paeoniflorin Attenuates Lipopolysaccharide-Induced Cognitive Dysfunction by Inhibition of Amyloidogenesis in MiceInternational Journal of Molecular SciencesMarch 2, 2023Hui Wen Meng, Ji-Hyun Kim, Hyun Young Kim, Ah Young Lee, Eun Ju Chocatalogue number 5606), presenilin1 (PS1, catalogue number 5643), and presenilin2 (PS2, catalogue number 9979) (1:1000 dilution; Cell Signaling Technology, Danvers, MA, USA). Subsequently, the membranes were incubated

(10) New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)International journal of molecular sciencesJanuary 12, 2023Li S, Han LL, Huang KP, Ma YH, Guo LL, Guo Y, Ran X, Yao YG, Hao XJ, Luo R, et al.(Cell Signaling Technology, 5665), PSEN1 (Cell Signaling Technology, 5643), PSEN2 (Cell Signaling Technology, 9979), phospho-CDK5 (Tyr15) (pCDK5) (Absin, abs130996). The membranes were washed 3 times with TBST (Tris-buffered

(11) JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiencyThe Journal of clinical investigationMarch 1, 2022Dave JM, Chakraborty R, Ntokou A, Saito J, Saddouk FZ, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, et al.anti-PSEN1 (Cell Signaling Technology, 5643; 1:100), rabbit anti-PSEN2 (Cell Signaling Technology, 9979; 1:100), rabbit anti–integrin β3 (Abcam, ab210515; 1:100), anti-HES1 (Cell Signaling Technology, 11988;

(12) Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-βFrontiers in physiologyJanuary 1, 2022Garcia J, Chang R, Steinberg RA, Arce A, Yang J, Van Der Eb P, Abdullah T, Chandrashekar DV, Eck SM, Meza P, et al.Tween-20. Antibodies to LRP1 (cat #64099), APP (cat #76600), Presenilin 1 (cat #5643), Presenilin 2 (cat #9979), GSK (cat #5676), and actin (cat #3700) were obtained from Cell Signaling Technology. The antibody

(13) A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu2+-Mediated Aβ AggregationInternational Journal of Molecular SciencesJune 25, 2021Xiaoyu Zhang, Xiancheng Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, He Xu, Tao Wang, Huiling Gaorabbit-anti-Presenilin 1 (5643, Cell Signaling Technology, Danvers, MA, USA), rabbit-anti-Presenilin 2 (9979, Cell Signaling Technology, Danvers, MA, USA), mouse-anti-Human sAPPβ-sw (10,321, IBL, Minneapolis,

(14) Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer's Disease ModelsFrontiers in aging neuroscienceJanuary 1, 2021Zhong M, Kou H, Zhao P, Zheng W, Xu H, Zhang X, Lan W, Guo C, Wang T, Guo F, et al.,Cell Signaling Technology anti-Presenilin 1 (D39D1)b,rabbit,5643,Cell Signaling Technology anti-Presenilin 2 (D30G3)b,rabbit,9979,Cell Signaling Technology anti-β-Actinb,mouse,A1978,Sigma-Aldrich anti-β-Amyloida,mouse,A8354,Sigma-Aldrich List

(15) Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutationsNeurobiology of DiseaseMay 1, 2020Anna A. Pimenova, Alison M. Goatefrom Santa Cruz, APP (A8717) and β-actin (A5441) from Sigma, PS1 CTF (D39D1, #5643), PS2 CTF (D30G3, #9979), Pen-2 (D6G8, #8598), Nicastrin (D38F9, #5665), Aβ (D54D2, #8243) from Cell Signaling. Transfection

(16) Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivoTheranosticsJanuary 1, 2020Fan J, Shen W, Lee SR, Mathai AE, Zhang R, Xu G, Gillies MC.,Cell Signaling#8828,Rabbit,1:1000 Presenilin 1,Cell Signaling#5643,Rabbit,1:1000 Presenilin 2,Cell Signaling#9979,Rabbit,1:1000 smad3,Cell Signaling#9523,Rabbit,1:1000 smad2/3,Cell Signaling#8685,Rabbit,1:1000 TGFβ-pan,Cell Signaling

(17) Angiogenic signaling in the lungs of a metabolically suppressed hibernating mammal (Ictidomys tridecemlineatus)PeerJNovember 18, 2019Samantha M. Logan, Kenneth B. Storeyconcentration of 2 µg/µL. Cell Signaling primary antibodies for nicastrin (Cat#5665), presenilin 2 (Cat#9979) and VEGFR2 (Cat#2479) were diluted 1:1000 v/v in TBST (50 mM Tris–HCl, 150 mM NaCl, 0.05% v/v Tween-20,

(18) Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model miceThe Journal of clinical investigationFebruary 1, 2019Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T.(1:1000; Cell Signaling Technology, catalog 5643), PS2 (1:1000; Cell Signaling Technology, catalog 9979), PEN2 (1:1000; Cell Signaling Technology, catalog 8502), phospho-tau (Ser416) (1:1000; Cell Signaling Technology

(19) Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockoutBrain communicationsJanuary 1, 2019Arber C, Villegas-Llerena C, Toombs J, Pocock JM, Ryan NS, Fox NC, Zetterberg H, Hardy J, Wray S.N-term,Millipore MAB1563,Rat PSEN1 C-term,Millipore MAB5232,Mouse PSEN2,Cell Signaling Technologies 9979,Rabbit NCSTN,BD Transduction Labs 612290,Mouse Actin,Sigma 1978,Mouse Antibodies used in this study

(20) Ipsilesional Motor Cortex Plasticity Participates in Spontaneous Hindlimb Recovery after Lateral Hemisection of the Thoracic Spinal Cord in the RatThe Journal of NeuroscienceNovember 14, 2018Andrew R. Brown, Marina MartinezMotor Cortex Plasticity after Spinal Hemisection J. Neurosci., November 14, 2018 • 38(46):9977–9988 • 9979 Figure 1. Spinal cord injury model and experimental design. A, Schematic representation of the SCI

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Presenilin 2 (D30G3) Rabbit mAb

Presenilin 2 (D30G3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Presenilin 2 (D30G3) Rabbit mAb from Cell Signaling Technology

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