RSK1 (D6D5) Rabbit mAb 8408S from Cell Signaling Technology

Product Specs
ItemRSK1 (D6D5) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8408S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R, Mk, B, Pg
TargetRSK1
HostRabbit
NCBI Gene AliasesHU-1, MAPKAPK1, MAPKAPK1A, RSK, RSK1, p90Rsk
ClonalityMonoclonal
NCBI Full Gene Nameribosomal protein S6 kinase A1
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD6D5
Molecular Weight90

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The critical role of the proto-oncogene c-Kit in TSC renal cystogenesisEMBO Molecular MedicineDecember 22, 2025Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Wenzheng Zhang, Jane J Yu, Nathan A Zaidman, Manoocher Soleimani(rabbit polyclonal),Cell Signaling Technology,4370S RSK1 (rabbit polyclonal),Cell Signaling Technology,8408T pRSK1 (rabbit polyclonal),Cell Signaling Technology,8753S AKT (rabbit polyclonal),Cell Signaling Technology,4691

(2) A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal CarcinomaCancer ScienceDecember 12, 2025Ming Zhang, Zhi‐Qiang Xiao, Wei Huang, Shan‐Shan Lu, Hong Yi, Juan FengPhospho‐EphA2 (Ser897; #6347), Phospho‐AKT (Ser473; #4060), Phospho‐RSK (Ser380; #9335), AKT (#4691), RSK (#8408), Phospho‐Histone H2A.X (Ser139; #9718), anti‐rabbit IgG (#7074), and anti‐mouse IgG (#7076) from Cell Signaling Technology

(3) Quantitative Proteomics of Nitrosylated Proteins in Melanoma Using the Biotin-Switch Technique Combined With Tandem Mass Tag LabelingBio ProtocDecember 5, 2025Vipin K. Yadav, Bin Fang, John M. Koomen, Jyoti Srivastava, Sanjay Premi(Cell Signaling Technology, catalog number: 3430S) 38. RSK-1 (Cell Signaling Technology, catalog number: 8408S) 39. GAPDH (Cell Signaling Technology, catalog number: 2118) 40. RASGAP (Proteintech, catalog number:

(4) Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockadeJournal of Clinical InvestigationSeptember 16, 2025Imran Khan, Aida Rodriguez-Brotons, Anukana Bhattacharjee, Vladimir Bezrookove, Altaf Dar, David De Semir, Mehdi Nosrati, Ryan Ice, Liliana Soroceanu, Stanley P. Leong, et al.pERK1/2 (catalog 9106), BCL2 (catalog 4223), tMEK (catalog 8727), pMEK (catalog 9154), tRSK (catalog 8408), pRSK (catalog 11989), and CDC20 (catalog 4823) from Cell Signaling Technology. The CDK1 (A303-663A)

(5) Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptorCommun BiolMarch 11, 2025Ryan J. Schuck, Alyssa E. Ward, Amita R. Sahoo, Jennifer A. Rybak, Robert J. Pyron, Thomas N. Trybala, Timothy B. Simmons, Joshua A. Baccile, Ioannis Sgouralis, Matthias Buck, et al.(CST 4060; 1:1000), rabbit anti-Akt (pan) (C67E7) (CST 4691; 1:1000), rabbit anti-RSK1 (D6D5) (CST 8408; 1:1000), rabbit anti-phospho-RSK1 (S380) (biotechne MAB 79671; 1:1000), rabbit anti-alpha-tubulin (CST

(6) Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interactionNucleic Acids ResearchFebruary 8, 2025Kirk L West, Tram T N Nguyen, Kyle A Tengler, Natasha Kreiling, Kevin D Raney, Gargi Ghosal, Justin W LeungPhosphothreonine (1:1000, New England Biolabs, 9386S), PCNA (1:1000, Abcam, ab92552), Chk1 (1:1000, Santa Cruz, 8408), Phospho-Chk1 Ser345 (1:1000, Cell Signaling, 2348S), Chk2 (1:1000 Cell Signaling, 3440S), Phospho-Chk2

(7) Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in LeiomyosarcomaClinical Cancer ResearchDecember 15, 2023Adrian Marino-Enriquez, Jan Philipp Novotny, Doga C. Gulhan, Isabella Klooster, Antuan V. Tran, Macy Kasbo, Meijun Z. Lundberg, Wen-Bin Ou, Derrick L. Tao, Daniel F. Pilco-Janeta, et al.1:200; PARP (9532, Cell Signaling), 1:1000; Cleaved PARP (#9541S, Cell Signaling), 1:1000; anti-CHK1 (#8408, Cell Signaling), 1:1000; anti-phospho-CHK1 Ser345 #2348, Cell Signaling), 1:1000; and anti-GAPDH (G8795,

(8) Inhibition of ERK signaling for treatment of ERRα positive TNBCPLOS ONEMay 10, 2023David Musheyev, Esther Miller, Natania Birnbaum, Elisheva Miller, Shoshana Erblich, Alyssa Schuck, Anya Alayev#13826, Phospho-p44/42 MAPK (ERK1) (Tyr204)/(ERK2) (Tyr187) #5726, Phospho-p90RSK1 (Ser380) #12032, RSK1 #8408, p44/42 MAPK (ERK1/2) #4695, Phospho-MAPK Substrates Motif [PXpTP] MultiMab™ #14378, Phospho-mTOR (Ser2448)

(9) Ribosomal S6 Kinase Regulates the Timing and Entrainment of the Mammalian Circadian Clock Located in the Suprachiasmatic NucleusNeuroscienceApril 15, 2023Hoyt KR, Li A, Yoon H, Weisenseel Z, Watkins J, Fischer A, Obrietan K.then incubated overnight at 4°C with one of the following antibodies: rabbit polyclonal RSK1 (D6D5; #8408; Cell Signaling Technologies; dilution: 1:500); rabbit polyclonal RSK2 (D21B2; #5528; Cell Signaling;

(10) MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approachFrontiers in Molecular BiosciencesApril 6, 2023Justine R. Stehn, Scott R. Floyd, Erik W. Wilker, H. Christian Reinhardt, Scott M. Clarke, Qiuying Huang, Roberto D. Polakiewicz, Nahum Sonenberg, Yi Wen Kong, Michael B. YaffePhospho-Thr-180/Tyr-182 p38 (#9211), were purchased from Cell Signaling Technologies. Antibodies against Chk1 (#8408), p38 (A-12, #sc-7972), pan 14-3-3 isoforms (K-19), and CDC25C (H-6, #sc-13138), as well as protein

(11) NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK InhibitionMolecular cancer therapeuticsDecember 2, 2022Llaurado Fernandez M, Hijmans EM, Gennissen AMC, Wong NKY, Li S, Wisman GBA, Hamilton A, Hoenisch J, Dawson A, Lee CH, et al.Santa Cruz Biotechnology; ACTIN (No. 3700), ERK (No. 4695), JUN (No. 2315), pS73JUN (No. 3270), PAX8 (No. 59019), RSK (No. 8408), pT359RSK (No. 8753), SHOC2 (No. 53600), cleaved NOTCH1 (No. 2421), NOTCH2 (No. 4530), NOTCH3 (No.

(12) Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancerCell Reports MedicineNovember 15, 2022Katrin J. Frank, Antonio Mulero-Sánchez, Alexandra Berninger, Laura Ruiz-Cañas, Astrid Bosma, Kıvanç Görgülü, Nan Wu, Kalliope N. Diakopoulos, Ezgi Kaya-Aksoy, Dietrich A. Ruess, et al.western blotting as described previously.23 The following antibodies were used: Antibodies against RSK-1 (8408), phosphorylated RSK-1 (9344 and 8753) and GAPDH (5174) were purchased from Cell Signaling Technology

(13) Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling PathwayAntioxidants (Basel, Switzerland)March 27, 2022Huynh DTN, Jin Y, Van Nguyen D, Myung CS, Heo KS.anti-ERK1/2 (#4695), rabbit anti-cyclin D1 (#2978), rabbit anti-phospho-p90RSK (#12032S), rabbit anti-RSK1 (#8408S), rabbit anti-phospho-Akt ser473 (#9271), rabbit anti-Akt (#9272), rabbit anti-vimentin (#5741), and

(14) Co-targeting MCL-1 and ERK1/2 kinase induces mitochondrial apoptosis in rhabdomyosarcoma cellsTranslational oncologyFebruary 1, 2022Winkler M, Friedrich J, Boedicker C, Dolgikh N.rabbit anti-p90 RSK (Ser380) (1:1000, Cell Signaling, 11989S), rabbit anti-RSK1 (1:1000, Cell Signaling, 8408S), mouse anti-PARP cleaved (1:1000, Cell Signaling, 9546S), rabbit anti-caspase-3 (1:1000, Cell Signaling,

(15) Regulatory factor identification for nodal genes in zebrafish by causal inferenceFrontiers in cell and developmental biologyJanuary 1, 2022Xing C, Zeng Z, Li Y, Gong B, Shen W, Shah R, Yan L, Du H, Meng A.mouse IgG (Biyuntian, A7028, 10 μg, as control), rabbit anti-β-catenin (Cell Signaling Technology, #8408, 20 μl), rabbit anti-Smad2/3 (Cell Signaling Technology, #3102, 30 μl) (Liu et al., 2011), and rabbit

(16) Plantar mechanical stimulation attenuates protein synthesis decline in disused skeletal muscle via modulation of nitric oxide levelScientific ReportsDecember 1, 2021Sergey A. Tyganov, Ekaterina Mochalova, Svetlana Belova, Kristina Sharlo, Sergey Rozhkov, Vitaliy Kalashnikov, Olga Turtikova, Timur Mirzoev, Boris Shenkmanp-p90RSK (Ser380) (1:1000, Cell Signaling, USA, #9341) and RSK1 (1:2000, Cell Signaling Technology, #8408). The membranes were incubated with horseradish peroxidase-conjugated secondary antibodies to rabbit

(17) RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemiaNature CommunicationsDecember 1, 2021Vasily V. Grinev et al.anti-RUNX1 (1:1000; cat. #4334S, Cell Signaling Technology), rabbit monoclonal anti-RPS6KA1 (1:1000; cat. #8408S, Cell Signaling Technology), mouse monoclonal anti-LIMS1 (1:1000; cat. #11890S, Cell Signaling Technology),

(18) A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancerScientific ReportsDecember 1, 2021Sander A. L. Palit, Jeroen van Dorp, Daniel Vis, Cor Lieftink, Simon Linder, Roderick Beijersbergen, Andries M. Bergman, Wilbert Zwart, Michiel S. van der Heijden(ThermoFisher Scientific). Antibodies directed against BRAF (14814), GAPDH (5174), t-ERK (9102), p-ERK (4377), t-RSK (8408) were purchased from Cell Signaling Technology; antibody against p-RSK (04-419) was purchased from Millipore;

(19) Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of transferrin receptorBMB ReportsMay 31, 2021Seong Heon Kim, Jin-hwa Cho, Bi-Oh Park, Byoung Chul Park, Jeong-Hoon Kim, Sung Goo Park, Sunhong KimT202/T204 (4370), anti-ERK1/2 (4695), anti-phospho RSK S380 (11989), anti-RSK1/2/3 (9355), anti-RSK1 (8408), anti-RSK2 (5528), anti-Myc (2278) were purchased from Cell Signaling Technology (Danvers, MA, USA).

(20) Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1ACell reportsJanuary 26, 2021Lee KY, Dutta A.anti-RNF8 (sc-271462), anti-RNF168 (sc-101125), anti-KU70 (sc-5309), anti-TLK2 (sc-393506), anti-Chk1 (sc-8408S), anti-Cyclin A (sc-751), anti-GST (sc-459), α-tubulin (sc-5286), anti-ATR (sc-1887) and anti-53BP1

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RSK1 (D6D5) Rabbit mAb

RSK1 (D6D5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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RSK1 (D6D5) Rabbit mAb from Cell Signaling Technology

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