ACO2 Antibody 6922S from Cell Signaling Technology

Product Specs
ItemACO2 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number6922S
NCBI Full Gene Nameaconitase 2
ApplicationsWB, ICC, IF
ReactivityHu, Ms, Rt, Mk
ClonalityPolyclonal
Research AreaMetabolism
Molecular Weight85
NCBI Gene AliasesACONM, HEL-S-284, ICRD, OCA8, OPA9
HostRabbit
TargetACO2
Quantity100 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor SuppressionCancer ResearchSeptember 2, 2025Natalia V. Oleinik, Firdevs Cansu Atilgan, Mohamed Faisal Kassir, Han Gyul Lee, Alhaji H. Janneh, Wyatt Wofford, Chase Walton, Zdzislaw M. Szulc, Elizabeth G. Hill, Alexander V. Alekseyenko, et al.and iNOS in cells. Antibodies The antibodies used for Western blotting in this study were: ACO2 (6922S, Cell Signaling Technology), LC3B (2775S, Cell Signaling Technology), DLP1 (611112, BD Transduction

(2) Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor SuppressionCancer ResSeptember 2, 2025Natalia V. Oleinik, Firdevs Cansu Atilgan, Mohamed Faisal Kassir, Han Gyul Lee, Alhaji H. Janneh, Wyatt Wofford, Chase Walton, Zdzislaw M. Szulc, Elizabeth G. Hill, Alexander V. Alekseyenko, et al.and iNOS in cells. Antibodies The antibodies used for Western blotting in this study were: ACO2 (6922S, Cell Signaling Technology), LC3B (2775S, Cell Signaling Technology), DLP1 (611112, BD Transduction

(3) Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenaseArchives of Biochemistry and BiophysicsMarch 1, 2025Kaylen R. Meeks, Juan Ji, Gary K. Scott, Ashley C. Campbell, Jay C. Nix, Ada Tadeo, Lisa M. Ellerby, Christopher C. Benz, John J. Tanner(sc-271609) antibodies were obtained from Santa Cruz Biotechnology. Rabbit polyclonal Aconitase 2 antibody (#6922) was obtained from Cell Signaling Technology. Rabbit polyclonal PRODH2 antibody (#PA5–62366) was obtained

(4) Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in miceiScienceFebruary 21, 2025Han Wang, Lizi Zhang, Xing Chen, Lingzi Hong, Junjie Zhao, Wen Qian, Lam Khue Pham, Belinda Willard, Xiaoxia Li, Katarzyna Bulek, et al.RRID:AB_10637855 Anti-β-Actin,Cell Signaling,Cat# 3700; RRID:AB_2242334 Anti-ACO2,Cell Signaling,Cat# 6922; RRID:AB_10828218 Anti-CYP1B1,ProteinTech,Cat# 18505-1-AP; RRID:AB_2878548 Anti-VDAC,Abcam,Cat# ab154856;

(5) Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxideMolecular CellMarch 7, 2024Marta Russo, Francesco Gualdrini, Veronica Vallelonga, Elena Prosperini, Roberta Noberini, Silvia Pedretti, Carolina Borriero, Pierluigi Di Di Chiaro, Sara Polletti, Gabriele Imperato, et al.Santa Cruz Biotechnology); DLAT (cat. no. 13426-1-AP, Proteintech); OGDH (cat. no. 15212-1-AP, Proteintech); ACO2 (cat. no. 6922S, Cell Signaling); HA (cat.no. 26183, Invitrogen). Co-immunoprecipitation Nuclear cell lysates were

(6) Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defectsAging cellOctober 1, 2023Oleinik N, Albayram O, Kassir MF, Atilgan FC, Walton C, Karakaya E, Kurtz J, Alekseyenko A, Alsudani H, Sheridan M, et al.sc‐517353, LC3B,Cell Signaling Technology Cat# 2775,RRID:AB_915950 ACO2,Cell Signaling Technology Cat# 6922S,RRID:AB_10828218 GFP,Thermo Fisher Scientific Cat# 14‐6774‐63,RRID:AB_468332 PDI,Novus Cat# NB100‐1921,RRID:AB_10001061 Cystein

(7) S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neuronsCell Chemical BiologyAugust 1, 2023Paschalis-Thomas Doulias, Hongmei Yang, Alexander Y. Andreyev, Nima Dolatabadi, Henry Scott, Charlene K K Raspur, Parth R. Patel, Tomohiro Nakamura, Steven R. Tannenbaum, Harry Ischiropoulos, et al.lipoamide dehydrogenase (DLD, Abcam, ab133551) and Aconitase 2 (Aco2 or AC, Cell Signaling Technologies, 6922S). After 3 washes with 1X TBS-T (Cell Signaling Technology, 9997S), the membranes were incubated with

(8) Neurobehavioral deficits of mice expressing a low level of G127V mutant frataxinNeurobiology of diseaseFebruary 1, 2023Fil D, Conley RL, Zuberi AR, Lutz CM, Gemelli T, Napierala M, Napierala JS.(anti-FXN, Proteintech 14147–1-AP; anti-HPRT, Proteintech 15059–1-AP; anti-Aconitase, Cell Signaling 6922; anti-Gapdh, Millipore MAB374) and secondary antibody (anti-Rabbit HRP linked, GE Healthcare NA934V

(9) The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemnessNature cell biologyJune 1, 2022Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, et al.anti-aldolase A (Santa Cruz Biotechnology, sc-390733; 1:500), anti-aconitase 2 (Cell Signaling Technology, 6922; 1:1,000), anti-citrate synthase (Abcam, ab129095; 1:1,000), anti-enolase (Cell Signaling Technology,

(10) Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell responseCell reportsMay 4, 2021Vaena S, Chakraborty P, Lee HG, Janneh AH, Kassir MF, Beeson G, Hedley Z, Yalcinkaya A, Sofi MH, Li H, et al.Lass5 (CerS5),Santa Cruz Biotechnology,sc-135038; RRID:AB_10609786 Anti-Aco2,Cell Signaling,"Cat# 6922S, RRID:AB_10828218" Anti-LC3B,Cell Signaling,"Cat# 2775, RRID:AB_915950" Anti-Tom20,Santa Cruz Biotechnology,"Cat#

(11) Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic CellsInternational journal of molecular sciencesOctober 16, 2020Calabrese C, Panuzzo C, Stanga S, Andreani G, Ravera S, Maglione A, Pironi L, Petiti J, Shahzad Ali MS, Scaravaglio P, et al.at RT, membranes were incubated overnight (ON) at 4 ◦ C with the primary antibodies (Aconitase 2, #6922, Cell Signaling Technology, Danvers, MA, USA, p21 sc-6246, Santa Cruz Biotechnology, Dallas, TX, USA,

(12) Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stressScience advancesSeptember 1, 2019Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, Lemasters JJ, Ogretmen B.XW-7119, RRID:AB_735674; ProSci), LC3B (cat# 2775, RRID:AB_915950; Cell Signaling Technology), ACO2 (cat# 6922S, RRID:AB_10828218; Cell Signaling Technology), GFP (cat# 14-6774-63, RRID:AB_468332; Thermo Fisher Scientific),

(13) Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related AnaloguesACS chemical biologyMay 17, 2019Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, et al.IDH2 (PA5-79436) from Invitrogen]; [ClpP (CS-14181), ATF4 (CS-11815), LONP (CS-28020), Aconitase (CS-6922s) from Cell Signaling Technologies]; [β-actin (SC-47778), CHOP (SC-575), TFAM, (SC-376672), ClpP (SC-271284)

(14) Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver CrosstalkCell reportsNovember 13, 2018Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, et al.,Cell Signaling Technology,,Cat#4870S; RRID: AB_2295614 Rabbit anti-Aco2,,Cell Signaling Technology,,Cat#6922S; RRID: AB_10828218 Mouse anti-NBR1 mAb (M01),,Abnova,,Cat#H00004077-M01; RRID: AB_1016849 Mouse anti-SQSTM1/P62,,Abnova,,Cat#H00008878-M01;

(15) NFATC2 is a novel therapeutic target for colorectal cancer stem cellsOncoTargets and TherapyNovember 10, 2018Tingyuan Lang, Xiaojuan Ding, Liangsheng Kong, Xiaoyan Zhou, Zhiqi Zhang, Huangxian Ju, Shijia Dingt-test. Abbreviations: CRC, colorectal cancer; NFATC2, nuclear factor of activated T-cells, cytoplasmic 2. 6922 Powered by TCPDF (www.tcpdf.org) submit your manuscript | www.dovepress.com Dovepress OncoTargets

(16) Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programingMolecular metabolismJanuary 1, 2018Gonzalez-Hurtado E, Lee J, Choi J, Wolfgang MJ.U6382), Ndufb8, Sdhb, Uqcrc2, Atp5a (MitoProfile total OXPHOS, Abcam; ab110413), Aco2 (Cell Signaling; 6922), Mcad (GeneTex; GTX32421), Pcx (Abcam; ab128952), Vdac (Calbiochem; PC548), Pdh E2/E3bp (Abcam; ab110333),

(17) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagyEMBO molecular medicineAugust 1, 2017Thomas RJ, Oleinik N, Panneer Selvam S, Vaena SG, Dany M, Nganga RN, Depalma R, Baron KD, Kim J, Szulc ZM, et al.Life Sciences); actin (A2066, Sigma, Inc.), Drp1 (BD# 611738, Clone 22/Drp1, BD Biosciences), ACO2 (#6922, Cell Signaling Technology); MFF (ab81127, Abcam); LC3 (D11 XP® mAb #3868, Cell Signaling Technology);

(18) The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic EfficiencyCell chemical biologyJune 22, 2017Bowman CE, Rodriguez S, Selen Alpergin ES, Acoba MG, Zhao L, Hartung T, Claypool SM, Watkins PA, Wolfgang MJ.polyclonal at 1:1000 (Calbiochem AB10527), aconitase 2 (ACO2) rabbit polyclonal at 1:1000 (Cell Signaling 6922), α-lipoic acid rabbit polyclonal at 1:1000 (Calbiochem #437695), phospho-ACC (Ser79) rabbit polyclonal

(19) Inhibition of prostate cancer proliferation by DeferiproneNMR in biomedicineJune 1, 2017Simões RV, Veeraperumal S, Serganova IS, Kruchevsky N, Varshavsky J, Blasberg RG, Ackerstaff E, Koutcher JA.Tris-buffered saline (TBS) with Tween-20 buffer and were immunoblotted with anti-m-Acon antibody (#6922; Cell Signaling Technology, Danvers, MA, USA) at a 1:1000 dilution. Bound primary antibodies were visualized

(20) Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunctionAmerican journal of physiology. Endocrinology and metabolismMay 1, 2017Gonzalez-Hurtado E, Lee J, Choi J, Selen Alpergin ES, Collins SL, Horton MR, Wolfgang MJ.(catalog no. 4047, Cell Signaling Technology), Acot7 [affinity-purified antibody (5)], Aco2 (catalog no. 6922, Cell Signaling Technology), Mcad (catalog no. GTX32421, GeneTex), Atp5a, Mtco1, and Uqcrc2 (MitoProfile

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ACO2 Antibody

ACO2 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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ACO2 Antibody from Cell Signaling Technology

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