K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb 5621S from Cell Signaling Technology

Product Specs
ItemK63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number5621S
Quantity100 µl
ApplicationsW
ReactivityAll
HostRabbit
ClonalityMonoclonal
Research AreaUbiquitin and Ubiquitin-like proteins
CloneD7A11

Add to Compare List

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytesSignal Transduct Target TherMay 18, 2026Xue Han, Zhuqi Huang, Guoxuan Liu, Yanan Liu, Weiqi Li, Jianing Zheng, Jie Tong, Mingyang He, Yurou Wu, Ze Li, et al.K48-linkage Specific Polyubiquitin Antibody (#4289, Cell Signaling Technology), K63-linkage Specific Polyubiquitin Antibody (#5621, Cell Signaling Technology), and GAPDH (60004-1-Ig, Proteintech). Deubiquitination assay HEK293T cells

(2) Ixazomib triggers autophagic degradation of MUC5AC/integrin-β4 and inhibits non-small cell lung cancer progressionCancer LettersMay 1, 2026Muthamil Iniyan Appadurai, Zahraa Wajih Alsafwani, Sanjib Chaudhary, Ashu Shah, Pranay Somavarapu, Sriman N. Dooshety, Ben S. Kubicek, Surinder K. Batra, Imayavaramban Lakshmanan, Apar Kishor Ganti(#3498), p21 (Cat. #2947), p27 (#3686), γH2AX (#80312), PI3K (#4249), UCHL1 (#33575), ubiquitin K-63 (#5621S) and RAD51 (#8875) were from Cell signaling Technology Inc. (MA, USA). p53 (sc-126), cyclin B1 (sc-245),

(3) OTUB1 stabilizes PRRSV matrix protein through a non-canonical deubiquitination mechanism to promote viral replicationJournal of VirologyApril 21, 2026Benjin Liu, Wenqi Liang, Xingyu Li, Shan Jiang, Ziqi Shi, Nian Liu, Rongsheng Zhu, Xuanzhi Dong, Han Zhou, Bin Zhou, et al.K63 linkage-specific polyubiquitin (D7A11) rabbit monoclonal antibody (for WB, 1:1,000; catalog no. 5621T), and ubiquitin (P4D1) mouse monoclonal antibody (for WB, 1:1,000; catalog no. 3936T) were obtained

(4) STING signaling in vestibular macrophages underlies Ménière’s disease pathogenesisJournal of NeuroinflammationApril 14, 2026Jiahui Liu, Na Li, Yurong Mu, Yongdong Song, Yao Lu, Xiaoxuan Xu, Na Zhang, Jing Wang, Xiaofei Li, Hanyue Wang, et al.(Cell Signaling Technology Cat# 12805, RRID: AB_2798031, used 1:1000), anti-K63-Ub (Cell Signaling Technology Cat# 5621, RRID: AB_10827985, used 1:1000), and anti-ACTIN (Thermo Fisher Scientific, Cat# MA5-11869, RRID: AB_11004139,

(5) SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactionsMicrobiology SpectrumApril 7, 2026Hui Yang, Daxin Peng, Luis Martinez-Sobrido, Chengjin Yeanti-IRF3 mAb (11904), rabbit anti-pIRF3 mAb (4947), rabbit anti-K63-linkage specific polyubiquitin mAb (5621), mouse anti-Phospho-Tyrosine (4G10) mAb (96215), rabbit anti-SARS-CoV-2 NSP3 polyclonal antibody (pAb)

(6) Inhibiting TRIM21 neddylation rejuvenates oocyte quality in PCOS by regulating ubiquitination of CPT1AResearch (Wash D C)April 3, 2026Xinni Na, Jin-Chi Liu, YINAN TAN, LINGBO MENG, CUISHAN GUO, NA ZUO, WANLIN DAI, Ruiting Cong, BOWEN ZHANG, WANTING SHI, et al.anti-ubiquitin K48 (Cell Signaling Technology, cat# 8081), anti-ubiquitin K48 (Cell Signaling Technology, cat# 5621), anti-α-tubulin (Cell Signaling Technology, cat# 5059), anti-ATP5A1 (Proteintech, cat# 14676-1-AP),

(7) The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degronsNature CommunicationsMarch 31, 2026Xiaodi Gong, Marlena Pożoga, Jean-Baptiste Boyer, Yuxing Xue, Thierry Meinnel, Tanja Bange, Carmela Giglione, Rüdiger Hell, Markus WirtzSanta-Cruz Biotechnology, sc-9996 HRP, 1:2,000), K48-Ubi (Cell signaling, 8081, 1:5,000), K63-Ubi (Cell signaling, 5621, 1:1,000), Neutravidin-HRP (Invitrogen, 31001, 1:10,000), mono- and poly-ubiquitination (Enzo life Sciences,

(8) SMURF1 Regulates CTCF ‐ HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal CarcinomaCancer ScienceMarch 3, 2026Ying Jin, Tian Zhang, Zhimin Wu, Yuanshan Liang, Yiting Jiang, Guodong Yuanti‐K48‐linked ubiquitin (#4289, Cell Signaling, Danvers, Massachusetts, USA), or anti‐K63‐linked ubiquitin (#5621, Cell Signaling) antibodies. Eluted proteins were analyzed by Western blot. To identify specific ubiquitination

(9) α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis modelsJ Clin InvestMarch 2, 2026Shuaijun Li, Jiefeng Huang, Ting Shang, Laiya Lu, Orion R. Fan, Peisheng Jin, Xin Zou, Zixin Cai, Wuyan Lu, Shuangmeng Jia, et al.AF5002; 1:1,000); TRAF6 (Santa Cruz Biotechnology; sc-8409; 1:200); K63 Ub (Cell Signaling Technology; 5621S; 1:1,000); and GAPDH (Abcam, ab8245; 1:2,000). After being washed with PBST, the membranes were incubated

(10) α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis modelsJ Clin InvestMarch 2, 2026Shuaijun Li, Jiefeng Huang, Ting Shang, Laiya Lu, Orion R. Fan, Peisheng Jin, Xin Zou, Zixin Cai, Wuyan Lu, Shuangmeng Jia, et al.AF5002; 1:1,000); TRAF6 (Santa Cruz Biotechnology; sc-8409; 1:200); K63 Ub (Cell Signaling Technology; 5621S; 1:1,000); and GAPDH (Abcam, ab8245; 1:2,000). After being washed with PBST, the membranes were incubated

(11) Cleavage‐Resistant CYLD Protects Against Autoimmune HepatitisAdvanced ScienceJanuary 28, 2026Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, et al.(1:20 000, Sigma, A8592‐1MG), K63‐linkage specific polyubiquitin (1:1000, Cell Signaling Technology, 5621). 4.9 Plasmids Murine Cyld, Mek1, Mek2, and Trim25 cDNAs were cloned into pcDNA3.0‐Flag, pcDNA3.1–3

(12) Coupling proteostasis and de novo purine biosynthesis of PSMD14 fuels glioblastoma progression and chemoresistanceTheranosticsJanuary 1, 2026Jiazheng Wang, Qun Cao, Zhikai Li, Xuxiu Lu, Zhuo Li, Chenghui Guo, Yuan Pan, Qing Zhang, Wenjie Li, Guo Xiang, et al.K48-linkage-specific polyubiquitin (8081S; 1:1,000; Cell Signaling Technology), K63-linkage-specific polyubiquitin (5621S; 1:1,000; Cell Signaling Technology), His-Tag (12698T; 1:1000; Cell Signaling Technology), HA-Tag (3724S;

(13) TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cellsCell Oncol (Dordr)December 29, 2025Tao Xie, Xiaoqi Fan, Tian Yu, Qing Zhu, Qi Zhang, Na Li, Tao Wang, Yisong Qian, Keyu Deng, Hongbo Xin, et al.(2947S), p27 (3686S), p38 (9212S), p-p38 (4511S), Akt (9272S), p-Akt (4060S), K63-linked specific Ub (5621S), K48-linked specific Ub (8081S), and Ub (3936S) were purchased from Cell Signaling Technology (Danvers,

(14) Ribosomal protein L35 negatively regulates FMDV replication by recruiting AMFR to promote the ubiquitination and degradation of VP2Journal of virologyNovember 25, 2025Shao W, Zhang W, Yang Y, Zhao X, Cao W, Chen C, Wang W, Huang M, Zhou T, Zhu Z, et al.anti-K48-linkage specific polyubiquitin (CST, Cat #4289), and anti-K63-linkage specific polyubiquitin (D7A11) (CST, Cat #5621). Secondary antibodies included Mouse anti-goat IgG/Alexa Fluor 594 (Invitrogen, Cat #A11005), Rabbit

(15) Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed TraitsAdvanced ScienceNovember 18, 2025Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, et al.(dilution 1:1000, Cat. # 3936s, Cell Signaling Technology, USA) and anti‐K63 (dilution 1:1000, Cat. # 5621s, Cell Signaling Technology, USA), were used. For secondary‐antibody detection, either goat anti‐mouse

(16) TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 proteinPLoS PathogOctober 23, 2025Yihan Wang, Li Jiang, Qibing Li, Mengya Li, Wenjun Shi, Bo Wang, Guangwen Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, et al.(Cell Signaling Technology, 8081S; 1:1000), rabbit anti-K63-linkage specific polyubiquitin mAb (Cell Signaling Technology, 5621S; 1:1000), mouse anti-Flag mAb (Sigma-Aldrich, F1804; 1:100), rabbit anti-Flag pAb (Sigma-Aldrich, F7425;

(17) Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting functionCell Death DisOctober 21, 2025Xingzhi Peng, Peijun Zhou, Kun Zhang, Likang Chen, Min Tang, Qin Zhou, Jinwu Peng, Lifang Yangfrom Santa Cruz Biotechnology (Santa Cruz, CA); Actin (AC026) from Abclonal (Wuhan, China). K63-Ub (#5621), K48-Ub (#8081), PDK1 (#3062), LDHA (#3582), PKM2 (#4053), and Histone H3 (#4499) from Cell Signaling Technology

(18) UBE2S inhibits colorectal cancer proliferation by regulating the PI3K/AKT and MAPK/ERK pathways via TRAF6Sci RepOctober 13, 2025Jun Li, Haoran Feng, Kun Liu, Haiyan Huang, Xiaopin Ji, Tao Zhang, Xi Cheng, Ren ZhaoPhospho-TAK1(1:1000, 9339, CST), HRP-conjugated GAPDH (1:1000, 3683, CST), K63-linkage Specific Polyubiquitin(1:1000, 5621, CST) and Ubiquitin (1:1000, 58395, CST). The secondary antibodies were respectively anti-mouse and

(19) Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell CarcinomaAdvanced science (Weinheim, Baden-Wurttemberg, Germany)October 1, 2025Lin X, Chen W, Li B, Zhao Z, Yu Z, Zhao XY, Zhou X, Feng Z, Lin C, Cao W.Polyubiquitin(#8081, CST, USA, dilution 1:1000, RRID: AB_10 859 893), K63‐linkage Specific Polyubiquitin(#5621, CST, USA, dilution 1:1000, RRID: AB_10 827 985), MYC (60003‐2‐Ig, Proteintech, USA, dilution 1:2000,

(20) USP13 stabilizes NLRP3 to facilitate inflammasome activation by preventing TRIM31-mediated NLRP3 ubiquitination and degradationScience AdvancesSeptember 26, 2025Ya-Ting Li, Ke-Ying Li, Shou-Song Tao, Ting Wang, Ying Lu, Hui Chen, Yi-Qun Zhan, Ke Zhao, Shen-Si Xiang, Jing-Jing Li, et al.Cell Signaling Technology, 4289), rabbit monoclonal anti–K63-Ubiquitin (1:500, Cell Signaling Technology, 5621), mouse monoclonal anti-mouse caspase-1 (1:1,000, Adipogen, AG-20B-0042), rabbit monoclonal anti-GSDMD

Be the First to Write a Review!

K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb

K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb from Cell Signaling Technology

Description

Cell Signaling Technology

Citations (224)

Reviews

K63-linkage Specific Polyubiquitin (D7A11) Rabbit mAb from Cell Signaling Technology

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map